Serial susceptibility weighted MRI measures brain iron and microbleeds in dementia

Wolff Kirsch*, Grant McAuley, Barbara Holshouser, Floyd Petersen, Muhammad Ayaz, Harry V. Vinters, Cindy Dickson, E. Mark Haacke, William Britt, James Larsen, Ivan Kim, Claudius Mueller, Matthew Schrag, Daniel Kido

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

113 Scopus citations


A new iron sensitive MR sequence (susceptibility weighted imaging - SWI) enabling the simultaneous quantitation of regional brain iron levels and brain microbleeds (BMB) has been acquired serially to study dementia. Cohorts of mildly cognitively impaired (MCI) elderly (n = 73) and cognitively normal participants (n = 33) have been serially evaluated for up to 50 months. SWI phase values (putative iron levels) in 14 brain regions were measured and the number of BMB were counted for each SWI study. SWI phase values showed a left putaminal mean increase of iron (decrease of phase values) over the study duration in 27 participants who progressed to dementia compared to Normals (p = 0.035) and stable MCI (p = 0.01). BMB were detected in 9 out of 26 (38%) MCI participants who progressed to dementia and are a significant risk factor for cognitive failure in MCI participants [risk ratio = 2.06 (95% confidence interval 1.37-3.12)]. SWI is useful to measure regional iron changes and presence of BMB, both of which may be important MR-based biomarkers for neurodegenerative diseases.

Original languageEnglish (US)
Pages (from-to)599-609
Number of pages11
JournalJournal of Alzheimer's Disease
Issue number3
StatePublished - 2009


  • Amyloid angiopathy
  • Brain
  • Cognitive impairment
  • Dementia
  • Globus pallidal iron
  • Microbleeds
  • Putaminal iron
  • Susceptibility weighted imaging

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Clinical Psychology
  • General Neuroscience


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