TY - JOUR
T1 - Serine protease inhibitor 6-deficient mice have increased neutrophil immunity to Pseudomonas aeruginosa
AU - Zhang, Manling
AU - Liu, Ni
AU - Park, Sun Mi
AU - Wang, Yue
AU - Byrne, Susan
AU - Murmann, Andrea E.
AU - Bahr, Scott
AU - Peter, Marcus E.
AU - Olson, Steven T.
AU - Belaaouaj, Abderrazzaq
AU - Ashton-Rickardt, Philip G.
PY - 2007/10/1
Y1 - 2007/10/1
N2 - Inflammation is a localized, protective response to trauma or microbial invasion that destroys the injurious agent and the injured tissue. Neutrophil elastase (NE), a serine protease stored in the azurophil granules of polymorphonuclear neutrophils, digests microbes after phagocytosis. NE can also digest microbes extracellularly but is associated with tissue damage and inflammatory disease. In this study, we show that polymorphonuclear neutrophils from mice deficient in serine protease inhibitor 6, a weak intracellular NE inhibitor, had increased susceptibility to self-inflicted lysis because of increased NE activity. The resulting transient increase in local extracellular NE activity was within a narrow range that resulted in the clearance of Pseudomonas aeruginosa but did not damage the lung. Therefore, deficiency in a weak intracellular inhibitor of NE results in an acute inflammatory response that protects from P. aeruginosa but does not cause lung disease.
AB - Inflammation is a localized, protective response to trauma or microbial invasion that destroys the injurious agent and the injured tissue. Neutrophil elastase (NE), a serine protease stored in the azurophil granules of polymorphonuclear neutrophils, digests microbes after phagocytosis. NE can also digest microbes extracellularly but is associated with tissue damage and inflammatory disease. In this study, we show that polymorphonuclear neutrophils from mice deficient in serine protease inhibitor 6, a weak intracellular NE inhibitor, had increased susceptibility to self-inflicted lysis because of increased NE activity. The resulting transient increase in local extracellular NE activity was within a narrow range that resulted in the clearance of Pseudomonas aeruginosa but did not damage the lung. Therefore, deficiency in a weak intracellular inhibitor of NE results in an acute inflammatory response that protects from P. aeruginosa but does not cause lung disease.
UR - http://www.scopus.com/inward/record.url?scp=45249123268&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=45249123268&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.179.7.4390
DO - 10.4049/jimmunol.179.7.4390
M3 - Article
C2 - 17878334
AN - SCOPUS:45249123268
VL - 179
SP - 4390
EP - 4396
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 7
ER -