Serologic and molecular analysis of the HLA system in Israeli Jewish patients with oral erosive lichen planus

A. Roitberg‐Tambur*, A. Friedmann, S. Korn, A. Markitziu, S. Pisanti, C. Satirman, D. Nelken, C. Brauthar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Abstract: Oral erosive lichen planus is a distinct subtype of the common dermatosis lichen planus. Although the etiology of lichen planus is still obscure, it is known that cell‐mediated immune mechanisms and genetic factors underlie its pathogenesis. Previous studies have found an association between lichen planus and HLA‐DR3 or DR9 in different population groups. The present work was designed to elucidate, at the serologic and molecular levels, whether and which HLA genes are associated with oral erosive lichen planus in Israeli Jewish patients. A significant association with HLA‐DR2 (RR = 4.7; pc < 0.0013) and a decrease in DR4 (RR = 0.3; p < 0.03) among the patients were noted. Oligotyping of DR2 alleles showed the presence of all three common variants (DRB1*1501, DRB1*1502 and DRB1*1601) in the patients, although none of the variants was overrepresented significantly. Three possible explanations for the role of HLA genes in the predisposition to oral erosive lichen planus are discussed. The most attractive theory for the pathogenesis of the disease seems to include the involvement of non‐classical HLA genes.

Original languageEnglish (US)
Pages (from-to)219-223
Number of pages5
JournalTissue Antigens
Volume43
Issue number4
DOIs
StatePublished - Apr 1994

Keywords

  • HLA
  • Jewish population
  • erosive lichen planus
  • oligotyping

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

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