Serologic evidence of active Epstein-barr virus infection in epstein-barr virus-associated lymphoproliferative disorders of children with acquired immunodeficiency syndrome

Ben Z. Katz*, Amy B. Berkman, Eugene D. Shapiro

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

The DNA and nuclear antigens of Epstein-Barr virus (EBV) have been detected in specimens of tissue of non-Hodgkin lymphoma and lymphocytic interstitial pneumonitis from patients with acquired immunodeficiency syndrome. To determine whether there is serologic evidence of an active EBV infection in these disorders, we conducted a case-control study. The case patients were 10 children with acquired immunodeficiency syndrome and EBV genome-positive pneumonitis or lymphoma. We randomly selected one or, if available, two matched control patients with human immunodeficiency virus infection for each index patient and compared their EBV serologic profiles with those of the index case patient at the time of the biopsy. Ten case patients and 13 matched control patients were enrolled. All 10 case patients (100%) compared with 2 (15%) of 13 matched control patients had serologic evidence of either a primary or a reactivated EBV infection at the time the index patient had a biopsy performed (p <0.001). Therefore we found serologic and virologic evidence that EBV is etiologically related to EBV-associated lymphocytic interstitial pneumonitis and non-Hodgkin lymphoma in children with acquired immunodeficiency syndrome.

Original languageEnglish (US)
Pages (from-to)228-232
Number of pages5
JournalThe Journal of pediatrics
Volume120
Issue number2 PART 1
DOIs
StatePublished - Feb 1992

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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