Serologic heterogeneity in I-J determinants associated with functionally distinct T cell regulatory factors

P. M. Flood, C. Waltenbaugh, T. Tada, B. Chue, D. B. Murphy

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Information transfer among regulatory T cell subsets is mediated by biologically active T cell factors. Many of these factors are comprised of two molecules: one that binds antigen, and another that is I-J+ and determines the self recognition capability of the factor (I-J molecule). In the in vitro response to sheep red blood cells, we used three functionally distinct I-J+ factors to study the relationship between polymorphic I-J determinants and the biological activity of these factors. Our study shows that several monoclonal I-J antibodies react with I-J molecules associated with T suppressor-inducer factor (TsiF) and T suppressor-effector factor (TseF), but not with T contrasuppressor inducer factor (TcsiF). In contrast, a different set of monoclonal I-J reagents reacts with TcsiF but not TsiF or TseF. Finally, some monoclonal I-J antibodies distinguish between I-J molecules associated with TsiF and TseF. Thus anti-I-J reagents differentially react with I-J determinants on regulatory factors, and this differential pattern of reactivity correlates with the functional activity of the factors. The possible relationship between I-J heterogeneity and the biological function of I-J molecules in regulation is discussed.

Original languageEnglish (US)
Pages (from-to)2237-2244
Number of pages8
JournalJournal of Immunology
Volume137
Issue number7
StatePublished - 1986

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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