Serologic response in blastomycosis: Diagnostic value of double immunodiffusion assay

J. E. Williams, R. Murphy, P. G. Standard, J. P. Phair

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Double immunodiffusion (DID) is a useful, inexpensive antibody screening test that is more specific than complement fixation for blastomycosis. Seven of 10 patients with proved blastomycosis had positive results on DID assays for antibody to the A antigen of Blastomyces dermatitidis. Sputum cytologic examination and skin or other tissue biopsies may be diagnostic if the organism is demonstrated. Culture remains the sina qua non of diagnosis, and a negative DID test result for A precipitin does not rule out this infection. Follow-up serologic studies of patients in remission and in relapse should be undertaken to determine the evolution of the immune response to the A antigen.

Original languageEnglish (US)
Pages (from-to)209-212
Number of pages4
JournalAmerican Review of Respiratory Disease
Issue number2
StatePublished - 1981

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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