Serological response to influenza vaccination among adults hospitalized with community-acquired pneumonia

Caroline Quinn Pratt, Yuwei Zhu, Carlos G. Grijalva, Richard G Wunderink, D Mark Courtney, Grant Waterer, Min Z. Levine, Stacie Jefferson, Wesley H. Self, Derek J. Williams, Lynn Finelli, Anna M. Bramley, Kathryn M. Edwards, Seema Jain, Evan J. Anderson

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Ninety-five adults enrolled in the Etiology of Pneumonia in the Community study with negative admission influenza polymerase chain reaction (PCR) tests received influenza vaccination during hospitalization. Acute and convalescent influenza serology was performed. After vaccination, seropositive (≥1:40) hemagglutination antibody titers (HAI) were achieved in 55% to influenza A(H1N1)pdm09, 58% to influenza A(H3N2), 77% to influenza B (Victoria), and 74% to influenza B (Yamagata) viruses. Sixty-six (69%) patients seroconverted (≥4-fold HAI rise) to ≥1 strain. Failure to seroconvert was associated with diabetes, bacterial detection, baseline seropositive titers for influenza B (Yamagata), and influenza vaccination in the previous season.

Original languageEnglish (US)
Pages (from-to)208-212
Number of pages5
JournalInfluenza and other respiratory viruses
Volume13
Issue number2
DOIs
StatePublished - Mar 1 2019

Fingerprint

Human Influenza
Pneumonia
Vaccination
Hemagglutination
Influenza B virus
Antibodies
Victoria
Serology
Hospitalization
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Epidemiology
  • Pulmonary and Respiratory Medicine
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Pratt, Caroline Quinn ; Zhu, Yuwei ; Grijalva, Carlos G. ; Wunderink, Richard G ; Courtney, D Mark ; Waterer, Grant ; Levine, Min Z. ; Jefferson, Stacie ; Self, Wesley H. ; Williams, Derek J. ; Finelli, Lynn ; Bramley, Anna M. ; Edwards, Kathryn M. ; Jain, Seema ; Anderson, Evan J. / Serological response to influenza vaccination among adults hospitalized with community-acquired pneumonia. In: Influenza and other respiratory viruses. 2019 ; Vol. 13, No. 2. pp. 208-212.
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abstract = "Ninety-five adults enrolled in the Etiology of Pneumonia in the Community study with negative admission influenza polymerase chain reaction (PCR) tests received influenza vaccination during hospitalization. Acute and convalescent influenza serology was performed. After vaccination, seropositive (≥1:40) hemagglutination antibody titers (HAI) were achieved in 55{\%} to influenza A(H1N1)pdm09, 58{\%} to influenza A(H3N2), 77{\%} to influenza B (Victoria), and 74{\%} to influenza B (Yamagata) viruses. Sixty-six (69{\%}) patients seroconverted (≥4-fold HAI rise) to ≥1 strain. Failure to seroconvert was associated with diabetes, bacterial detection, baseline seropositive titers for influenza B (Yamagata), and influenza vaccination in the previous season.",
author = "Pratt, {Caroline Quinn} and Yuwei Zhu and Grijalva, {Carlos G.} and Wunderink, {Richard G} and Courtney, {D Mark} and Grant Waterer and Levine, {Min Z.} and Stacie Jefferson and Self, {Wesley H.} and Williams, {Derek J.} and Lynn Finelli and Bramley, {Anna M.} and Edwards, {Kathryn M.} and Seema Jain and Anderson, {Evan J.}",
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Pratt, CQ, Zhu, Y, Grijalva, CG, Wunderink, RG, Courtney, DM, Waterer, G, Levine, MZ, Jefferson, S, Self, WH, Williams, DJ, Finelli, L, Bramley, AM, Edwards, KM, Jain, S & Anderson, EJ 2019, 'Serological response to influenza vaccination among adults hospitalized with community-acquired pneumonia', Influenza and other respiratory viruses, vol. 13, no. 2, pp. 208-212. https://doi.org/10.1111/irv.12622

Serological response to influenza vaccination among adults hospitalized with community-acquired pneumonia. / Pratt, Caroline Quinn; Zhu, Yuwei; Grijalva, Carlos G.; Wunderink, Richard G; Courtney, D Mark; Waterer, Grant; Levine, Min Z.; Jefferson, Stacie; Self, Wesley H.; Williams, Derek J.; Finelli, Lynn; Bramley, Anna M.; Edwards, Kathryn M.; Jain, Seema; Anderson, Evan J.

In: Influenza and other respiratory viruses, Vol. 13, No. 2, 01.03.2019, p. 208-212.

Research output: Contribution to journalArticle

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AU - Zhu, Yuwei

AU - Grijalva, Carlos G.

AU - Wunderink, Richard G

AU - Courtney, D Mark

AU - Waterer, Grant

AU - Levine, Min Z.

AU - Jefferson, Stacie

AU - Self, Wesley H.

AU - Williams, Derek J.

AU - Finelli, Lynn

AU - Bramley, Anna M.

AU - Edwards, Kathryn M.

AU - Jain, Seema

AU - Anderson, Evan J.

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