Serotonergic measures in suicide brain: 5-HT1A binding sites in frontal cortex of suicide victims

S. Matsubara*, R. C. Arora, H. Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

125 Scopus citations


The density of 5-HT1A binding using3H-8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) as binding ligand, was studied in human frontal cortex of suicide victims and normal controls who died due to medical disease or accidentally. There was no difference in the maximum number of binding site (Bmax) or Kd (an inverse measure of affinity) of 5-HT1A receptor binding sites between normal controls and the entire group of suicide victims. However, nonviolent suicides had significantly higher Bmax (22-25%) compared to both controls and violent suicides. A negative correlation between age and Bmax of 5-HT1A binding sites was found in male controls but not in female controls or suicide victims. This relationship was less apparent among the male controls over age 60.

Original languageEnglish (US)
Pages (from-to)181-194
Number of pages14
JournalJournal of Neural Transmission
Issue number3
StatePublished - Oct 1991


  • Serotonin (5-HT) receptor
  • brain
  • suicide

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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