TY - JOUR
T1 - Serotonergic neurotoxic lesions facilitate male sexual reflexes
AU - Marson, Lesley
AU - McKenna, Kevin E.
N1 - Funding Information:
The authors would like to thank Dr. Jon Levine for the use of his HPLC supported by HD 28048 and Marsha List for excellent technical support. This work was supported by NIH grant numbers NS29420 awarded to Lesley Marson and NS17489 awarded to Kevin E. McKenna.
PY - 1994/4
Y1 - 1994/4
N2 - The effects of the neurotoxin 5,7 dihydroxytryptamine (5,7 DHT) on the urethrogenital reflex was examined in anesthetized male rats. Both ICV and intrathecal administration of 5,7 DHT produced a marked depletion (92%) of spinal 5-hydroxytryptamine (5-HT) and 5-hydroxyindole acetic acid (5-HT IAA) levels. ICV but not intrathecal administration of 5,7 DHT also caused a moderate reduction in 5-HT and 5-HT IAA levels in the medulla and hypothalamus (40-48%). No reduction in adrenergic levels were observed. In spinally intact, vehicle-treated rats the urethrogenital reflex could not be evoked. However, the urethrogenital reflex could be evoked in rats pretreated with either ICV or intrathecal 5,7 DHT prior to section of the spinal cord. These data support the hypothesis that 5-HT mediates the descending inhibition of male sexual reflexes.
AB - The effects of the neurotoxin 5,7 dihydroxytryptamine (5,7 DHT) on the urethrogenital reflex was examined in anesthetized male rats. Both ICV and intrathecal administration of 5,7 DHT produced a marked depletion (92%) of spinal 5-hydroxytryptamine (5-HT) and 5-hydroxyindole acetic acid (5-HT IAA) levels. ICV but not intrathecal administration of 5,7 DHT also caused a moderate reduction in 5-HT and 5-HT IAA levels in the medulla and hypothalamus (40-48%). No reduction in adrenergic levels were observed. In spinally intact, vehicle-treated rats the urethrogenital reflex could not be evoked. However, the urethrogenital reflex could be evoked in rats pretreated with either ICV or intrathecal 5,7 DHT prior to section of the spinal cord. These data support the hypothesis that 5-HT mediates the descending inhibition of male sexual reflexes.
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U2 - 10.1016/0091-3057(94)90292-5
DO - 10.1016/0091-3057(94)90292-5
M3 - Article
C2 - 7518085
AN - SCOPUS:0028230880
VL - 47
SP - 883
EP - 888
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
SN - 0091-3057
IS - 4
ER -