Serotonin uptake by blood platelets of schizophrenic patients

Ramesh C. Arora; Herbert Y. Meltzer

doi:10.1016/0165-1781(82)90022-1

Serotonin uptake by blood platelets of schizophrenic patients

Ramesh C. Arora^*, Herbert Y. Meltzer

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Active uptake of serotonin (5-hydroxytryptamine, 5-HT) by blood platelets of acute and chronic schizophrenic patients was compared with that of normal controls. Unlike previous reports, no significant difference in the kinetic parameters (Km and Vmax) of 5-HT uptake between schizophrenic patients and normal controls was observed, although a trend toward decreased Vmax in the acute schizophrenics was present. Since decreased Vmax of platelet 5-HT uptake has been found in patients with bipolar, unipolar, and schizoaffective depression, further study of the usefulness of platelet 5-HT uptake as a biological marker for major depressive illness is indicated. Abnormalities of 5-HT uptake do not appear to contribute significantly to the increased platelet 5-HT levels which have been reported in schizophrenic patients.

Original language	English (US)
Pages (from-to)	327-333
Number of pages	7
Journal	Psychiatry Research
Volume	6
Issue number	3
DOIs	https://doi.org/10.1016/0165-1781(82)90022-1
State	Published - Jun 1982

Keywords

Platelet, serotonin uptake, schizophrenia, Vmax

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0165-1781(82)90022-1

Cite this

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title = "Serotonin uptake by blood platelets of schizophrenic patients",

abstract = "Active uptake of serotonin (5-hydroxytryptamine, 5-HT) by blood platelets of acute and chronic schizophrenic patients was compared with that of normal controls. Unlike previous reports, no significant difference in the kinetic parameters (Km and Vmax) of 5-HT uptake between schizophrenic patients and normal controls was observed, although a trend toward decreased Vmax in the acute schizophrenics was present. Since decreased Vmax of platelet 5-HT uptake has been found in patients with bipolar, unipolar, and schizoaffective depression, further study of the usefulness of platelet 5-HT uptake as a biological marker for major depressive illness is indicated. Abnormalities of 5-HT uptake do not appear to contribute significantly to the increased platelet 5-HT levels which have been reported in schizophrenic patients.",

keywords = "Platelet, serotonin uptake, schizophrenia, Vmax",

author = "Arora, {Ramesh C.} and Meltzer, {Herbert Y.}",

note = "Funding Information: Acknowledgment. This research was supported in part by USPHS MH-30,938 and MH-30,059 and by the Department of Mental Health, State of Illinois. HYM is recipient of USPHS MH-RCSA-47,808.",

year = "1982",

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doi = "10.1016/0165-1781(82)90022-1",

language = "English (US)",

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journal = "Psychiatry Research",

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T1 - Serotonin uptake by blood platelets of schizophrenic patients

AU - Arora, Ramesh C.

AU - Meltzer, Herbert Y.

N1 - Funding Information: Acknowledgment. This research was supported in part by USPHS MH-30,938 and MH-30,059 and by the Department of Mental Health, State of Illinois. HYM is recipient of USPHS MH-RCSA-47,808.

PY - 1982/6

Y1 - 1982/6

N2 - Active uptake of serotonin (5-hydroxytryptamine, 5-HT) by blood platelets of acute and chronic schizophrenic patients was compared with that of normal controls. Unlike previous reports, no significant difference in the kinetic parameters (Km and Vmax) of 5-HT uptake between schizophrenic patients and normal controls was observed, although a trend toward decreased Vmax in the acute schizophrenics was present. Since decreased Vmax of platelet 5-HT uptake has been found in patients with bipolar, unipolar, and schizoaffective depression, further study of the usefulness of platelet 5-HT uptake as a biological marker for major depressive illness is indicated. Abnormalities of 5-HT uptake do not appear to contribute significantly to the increased platelet 5-HT levels which have been reported in schizophrenic patients.

AB - Active uptake of serotonin (5-hydroxytryptamine, 5-HT) by blood platelets of acute and chronic schizophrenic patients was compared with that of normal controls. Unlike previous reports, no significant difference in the kinetic parameters (Km and Vmax) of 5-HT uptake between schizophrenic patients and normal controls was observed, although a trend toward decreased Vmax in the acute schizophrenics was present. Since decreased Vmax of platelet 5-HT uptake has been found in patients with bipolar, unipolar, and schizoaffective depression, further study of the usefulness of platelet 5-HT uptake as a biological marker for major depressive illness is indicated. Abnormalities of 5-HT uptake do not appear to contribute significantly to the increased platelet 5-HT levels which have been reported in schizophrenic patients.

KW - Platelet, serotonin uptake, schizophrenia, Vmax

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ER -

Serotonin uptake by blood platelets of schizophrenic patients

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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