Serotonin (5‐HT) uptake was studied in the blood platelets of 10 patients with Duchenne‐type muscular dystrophy (DMD) and 7 age‐matched controls. Vmax (maximum number of uptake sites) of platelet 5‐HT uptake in the DMD patients was significantly less than that of the normal controls. There was no difference in the affinity for 5‐HT (Km) between the two groups. There was a significant negative correlation between serum creatine kinase activity and Km of 5‐HT uptake in blood platelets of these patients. However, no correlation was found between Km or Vmax and ambulatory status of DMD.
ASJC Scopus subject areas
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Physiology (medical)