Serotonin Uptake in Blood Platelets of Psychiatric Patients

Herbert Y. Meltzer; Ramesh C. Arora; Riaz Baber; Betty Tricou

doi:10.1001/archpsyc.1981.01780370024002

Serotonin Uptake in Blood Platelets of Psychiatric Patients

Herbert Y. Meltzer^*, Ramesh C. Arora, Riaz Baber, Betty Tricou

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

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Abstract

Platelet serotonin (5-HT) uptake was determined in 72 newly admitted, unmedicated psychiatric patients. Decreased maximum velocity (V_max) of 5-HT uptake was present in unipolar and bipolar depressed patients as well as schizoaffective depressed patients. The apparent Michaelis constant (k_m) of 5-HT uptake was normal in these groups, as was V_max and K_m in manicdepressive and chronic schizophrenic patients. Treatment of depressed patients with notriptyline hydrochloride or imipramine hydrochloride increased K_m significantly. There was a trend for the increase in K_m in the nortriptyline-treated patients to correlate with clinical improvement. Decreased 5-HT uptake in platelets provides additional evidence for the role of 5-HT in the pathophysiologic process of some forms of depression.

Original language	English (US)
Pages (from-to)	1322-1326
Number of pages	5
Journal	Archives of general psychiatry
Volume	38
Issue number	12
DOIs	https://doi.org/10.1001/archpsyc.1981.01780370024002
State	Published - Dec 1981

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Psychiatry and Mental health

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10.1001/archpsyc.1981.01780370024002

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title = "Serotonin Uptake in Blood Platelets of Psychiatric Patients",

abstract = "Platelet serotonin (5-HT) uptake was determined in 72 newly admitted, unmedicated psychiatric patients. Decreased maximum velocity (Vmax) of 5-HT uptake was present in unipolar and bipolar depressed patients as well as schizoaffective depressed patients. The apparent Michaelis constant (km) of 5-HT uptake was normal in these groups, as was Vmax and Km in manicdepressive and chronic schizophrenic patients. Treatment of depressed patients with notriptyline hydrochloride or imipramine hydrochloride increased Km significantly. There was a trend for the increase in Km in the nortriptyline-treated patients to correlate with clinical improvement. Decreased 5-HT uptake in platelets provides additional evidence for the role of 5-HT in the pathophysiologic process of some forms of depression.",

author = "Meltzer, {Herbert Y.} and Arora, {Ramesh C.} and Riaz Baber and Betty Tricou",

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AU - Meltzer, Herbert Y.

AU - Arora, Ramesh C.

AU - Baber, Riaz

AU - Tricou, Betty

PY - 1981/12

Y1 - 1981/12

N2 - Platelet serotonin (5-HT) uptake was determined in 72 newly admitted, unmedicated psychiatric patients. Decreased maximum velocity (Vmax) of 5-HT uptake was present in unipolar and bipolar depressed patients as well as schizoaffective depressed patients. The apparent Michaelis constant (km) of 5-HT uptake was normal in these groups, as was Vmax and Km in manicdepressive and chronic schizophrenic patients. Treatment of depressed patients with notriptyline hydrochloride or imipramine hydrochloride increased Km significantly. There was a trend for the increase in Km in the nortriptyline-treated patients to correlate with clinical improvement. Decreased 5-HT uptake in platelets provides additional evidence for the role of 5-HT in the pathophysiologic process of some forms of depression.

AB - Platelet serotonin (5-HT) uptake was determined in 72 newly admitted, unmedicated psychiatric patients. Decreased maximum velocity (Vmax) of 5-HT uptake was present in unipolar and bipolar depressed patients as well as schizoaffective depressed patients. The apparent Michaelis constant (km) of 5-HT uptake was normal in these groups, as was Vmax and Km in manicdepressive and chronic schizophrenic patients. Treatment of depressed patients with notriptyline hydrochloride or imipramine hydrochloride increased Km significantly. There was a trend for the increase in Km in the nortriptyline-treated patients to correlate with clinical improvement. Decreased 5-HT uptake in platelets provides additional evidence for the role of 5-HT in the pathophysiologic process of some forms of depression.

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Serotonin Uptake in Blood Platelets of Psychiatric Patients

Abstract

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