Serotonin uptake in subpopulations of normal human blood platelets

R. C. Arora, H. Y. Meltzer

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Serotonin uptake was studied in platelet-rich plasma with different proportions of heavy (young) and light (old) platelets. The maximum velocity of serotonin uptake, a measure of the number of uptake sites (Vmax), was greater in the heavy platelets than in the light platelets. However, the uptake sites in the lighter platelets had an increased affinity (Km) for serotonin compared to the heavy platelets, which could compensate for the decreased number of uptake sites. These results indicate differences in Vmax of 5-HT uptake in particular populations could be due to differences in the relative proportions of heavy and light platelets.

Original languageEnglish (US)
Pages (from-to)1157-1162
Number of pages6
JournalBiological Psychiatry
Volume17
Issue number10
StatePublished - Dec 1 1982

ASJC Scopus subject areas

  • Biological Psychiatry

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