Abstract
We determined serotonin (5-HT) uptake in the blood platelets of Alzheimer’s disease (AD) patients and comparable age-matched normal controls. The maximum number of 5-HT uptake sites (Vmax) was significantly increased in mild and moderate AD patients, and a trend toward decreased Vmax was observed in severe AD patients as compared with normal controls. The Km of 5-HT uptake was negatively correlated with the Face-Hand Test (FHT) score of severely ill AD patients, whereas Vmax was correlated with the FHT score and the Mental Status Questionnaire score in the entire AD sample.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1307-1309 |
| Number of pages | 3 |
| Journal | Neurology |
| Volume | 41 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 1991 |
ASJC Scopus subject areas
- Clinical Neurology
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Arora, R. C., Emery, O. B., & Meltzer, H. Y. (1991). Serotonin uptake in the blood platelets of alzheimer’s disease patients. Neurology, 41(8), 1307-1309. https://doi.org/10.1212/wnl.41.8.1307