Serotonin uptake in the blood platelets of alzheimer’s disease patients

Ramesh C. Arora; Olga B. Emery; Herbert Y. Meltzer

doi:10.1212/wnl.41.8.1307

Serotonin uptake in the blood platelets of alzheimer’s disease patients

Ramesh C. Arora^*, Olga B. Emery, Herbert Y. Meltzer

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

We determined serotonin (5-HT) uptake in the blood platelets of Alzheimer’s disease (AD) patients and comparable age-matched normal controls. The maximum number of 5-HT uptake sites (V_max) was significantly increased in mild and moderate AD patients, and a trend toward decreased V_max was observed in severe AD patients as compared with normal controls. The K_m of 5-HT uptake was negatively correlated with the Face-Hand Test (FHT) score of severely ill AD patients, whereas V_max was correlated with the FHT score and the Mental Status Questionnaire score in the entire AD sample.

Original language	English (US)
Pages (from-to)	1307-1309
Number of pages	3
Journal	Neurology
Volume	41
Issue number	8
DOIs	https://doi.org/10.1212/wnl.41.8.1307
State	Published - Aug 1991

ASJC Scopus subject areas

Clinical Neurology

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author = "Arora, {Ramesh C.} and Emery, {Olga B.} and Meltzer, {Herbert Y.}",

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AU - Meltzer, Herbert Y.

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AB - We determined serotonin (5-HT) uptake in the blood platelets of Alzheimer’s disease (AD) patients and comparable age-matched normal controls. The maximum number of 5-HT uptake sites (Vmax) was significantly increased in mild and moderate AD patients, and a trend toward decreased Vmax was observed in severe AD patients as compared with normal controls. The Km of 5-HT uptake was negatively correlated with the Face-Hand Test (FHT) score of severely ill AD patients, whereas Vmax was correlated with the FHT score and the Mental Status Questionnaire score in the entire AD sample.

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Serotonin uptake in the blood platelets of alzheimer’s disease patients

Abstract

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