Serotonin uptake in the blood platelets of alzheimer’s disease patients

Ramesh C. Arora; Olga B. Emery; Herbert Y. Meltzer

doi:10.1212/wnl.41.8.1307

Serotonin uptake in the blood platelets of alzheimer’s disease patients

Ramesh C. Arora^*, Olga B. Emery, Herbert Y. Meltzer

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

We determined serotonin (5-HT) uptake in the blood platelets of Alzheimer’s disease (AD) patients and comparable age-matched normal controls. The maximum number of 5-HT uptake sites (V_max) was significantly increased in mild and moderate AD patients, and a trend toward decreased V_max was observed in severe AD patients as compared with normal controls. The K_m of 5-HT uptake was negatively correlated with the Face-Hand Test (FHT) score of severely ill AD patients, whereas V_max was correlated with the FHT score and the Mental Status Questionnaire score in the entire AD sample.

Original language	English (US)
Pages (from-to)	1307-1309
Number of pages	3
Journal	Neurology
Volume	41
Issue number	8
DOIs	https://doi.org/10.1212/wnl.41.8.1307
State	Published - Aug 1991

ASJC Scopus subject areas

Clinical Neurology

Access to Document

10.1212/wnl.41.8.1307

Cite this

@article{9aa28ef89a084fc0b3d3404e0e8466d5,

title = "Serotonin uptake in the blood platelets of alzheimer{\textquoteright}s disease patients",

abstract = "We determined serotonin (5-HT) uptake in the blood platelets of Alzheimer{\textquoteright}s disease (AD) patients and comparable age-matched normal controls. The maximum number of 5-HT uptake sites (Vmax) was significantly increased in mild and moderate AD patients, and a trend toward decreased Vmax was observed in severe AD patients as compared with normal controls. The Km of 5-HT uptake was negatively correlated with the Face-Hand Test (FHT) score of severely ill AD patients, whereas Vmax was correlated with the FHT score and the Mental Status Questionnaire score in the entire AD sample.",

author = "Arora, {Ramesh C.} and Emery, {Olga B.} and Meltzer, {Herbert Y.}",

year = "1991",

month = aug,

doi = "10.1212/wnl.41.8.1307",

language = "English (US)",

volume = "41",

pages = "1307--1309",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams and Wilkins",

number = "8",

}

TY - JOUR

T1 - Serotonin uptake in the blood platelets of alzheimer’s disease patients

AU - Arora, Ramesh C.

AU - Emery, Olga B.

AU - Meltzer, Herbert Y.

PY - 1991/8

Y1 - 1991/8

N2 - We determined serotonin (5-HT) uptake in the blood platelets of Alzheimer’s disease (AD) patients and comparable age-matched normal controls. The maximum number of 5-HT uptake sites (Vmax) was significantly increased in mild and moderate AD patients, and a trend toward decreased Vmax was observed in severe AD patients as compared with normal controls. The Km of 5-HT uptake was negatively correlated with the Face-Hand Test (FHT) score of severely ill AD patients, whereas Vmax was correlated with the FHT score and the Mental Status Questionnaire score in the entire AD sample.

AB - We determined serotonin (5-HT) uptake in the blood platelets of Alzheimer’s disease (AD) patients and comparable age-matched normal controls. The maximum number of 5-HT uptake sites (Vmax) was significantly increased in mild and moderate AD patients, and a trend toward decreased Vmax was observed in severe AD patients as compared with normal controls. The Km of 5-HT uptake was negatively correlated with the Face-Hand Test (FHT) score of severely ill AD patients, whereas Vmax was correlated with the FHT score and the Mental Status Questionnaire score in the entire AD sample.

UR - http://www.scopus.com/inward/record.url?scp=0025812899&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025812899&partnerID=8YFLogxK

U2 - 10.1212/wnl.41.8.1307

DO - 10.1212/wnl.41.8.1307

M3 - Article

C2 - 1866025

AN - SCOPUS:0025812899

SN - 0028-3878

VL - 41

SP - 1307

EP - 1309

JO - Neurology

JF - Neurology

IS - 8

ER -

Serotonin uptake in the blood platelets of alzheimer’s disease patients

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this