Serotonin uptake in the blood platelets of alzheimer’s disease patients

Ramesh C. Arora*, Olga B. Emery, Herbert Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

We determined serotonin (5-HT) uptake in the blood platelets of Alzheimer’s disease (AD) patients and comparable age-matched normal controls. The maximum number of 5-HT uptake sites (Vmax) was significantly increased in mild and moderate AD patients, and a trend toward decreased Vmax was observed in severe AD patients as compared with normal controls. The Km of 5-HT uptake was negatively correlated with the Face-Hand Test (FHT) score of severely ill AD patients, whereas Vmax was correlated with the FHT score and the Mental Status Questionnaire score in the entire AD sample.

Original languageEnglish (US)
Pages (from-to)1307-1309
Number of pages3
JournalNeurology
Volume41
Issue number8
DOIs
StatePublished - Aug 1991

ASJC Scopus subject areas

  • Clinical Neurology

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