Serotonin1A receptors are increased in postmortem prefrontal cortex in schizophrenia

Tomiki Sumiyoshi, Craig A. Stockmeier, James C. Overholser, Ginny E. Dilley, Herbert Y. Meltzer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

147 Scopus citations

Abstract

Serotonin-5-HT1A receptors were measured with [3H]8-hydroxy-2-(di-n-propyl)aminotetralin ([3H]8-OH-DPAT) in postmortem prefrontal cortex of 12 pairs of subjects with schizophrenia and age-matched control subjects. The saturation binding isotherms of [3H]S-OH-DPAT revealed high-and low-affinity binding sites. The density (Bmax) of the high-affinity sites was significantly elevated by an average of 79% in subjects with schizophrenia. The dissociation constant (Kd) of the high-affinity sites in subjects with schizophrenia was not significantly different from the control subjects. These results provide further evidence for a role of the serotonergic system in the pathophysiology of schizophrenia.

Original languageEnglish (US)
Pages (from-to)209-214
Number of pages6
JournalBrain research
Volume708
Issue number1-2
DOIs
StatePublished - Feb 5 1996

Keywords

  • Postmortem brain
  • Prefrontal cortex
  • Receptor
  • Schizophrenia
  • Serotonin-5-HT
  • Up-regulation
  • [H]S-OH-DPAT

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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