Serotonin2 (5-HT2) receptor binding in the frontal cortex of schizophrenic patients

R. C. Arora*, H. Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

142 Scopus citations

Abstract

Serotonin2 (5-HT2) receptor binding was studied, using3H-spiperone as the ligand, in post-mortem brain specimens obtained from schizophrenic patients (N=11) and non-psychiatric controls (N=11). The maximum number of binding sites (Bmax) was significantly decreased in schizophrenic patients as compared to normal controls. This difference did not appear to be due to neuroleptic treatment. No difference in Kd (an inverse measure of the affinity of3H-spiperone to its binding sites) was observed between the two groups. However, studies with unmedicated schizophrenic patients are needed to draw any definite conclusion. The role of serotonergic processes in the psychobiology of schizophrenia is discussed.

Original languageEnglish (US)
Pages (from-to)19-29
Number of pages11
JournalJournal of Neural Transmission
Volume85
Issue number1
DOIs
StatePublished - Feb 1991

Keywords

  • 5-HT receptor
  • human postmortem brain
  • schizophrenia

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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