Serotonin2 receptor binding in blood platelets of schizophrenic patients

Ramesh C. Arora, Herbert Y. Meltzer

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Platelet serotonin2 (5-HT2) binding was determined in 47 neuroleptic-free schizophrenic patients and 42 normal control subjects. Although the maximum number of 5-HT2 binding sites (Bmax) was significantly higher in the blood platelets of schizophrenic patients than in those of the normal control subjects, the difference disappeared after correction for age and sex effects. However, the Bmax of schizophrenic patients who had made suicide attempts was significantly greater than that of schizophrenic patients who had not, as well as that of normal controls. There was no difference in Kd between the schizophrenic patients and control subjects, and no relation between Kd and suicide attempts. The importance of serotonin in schizophrenia and suicide attempts is discussed.

Original languageEnglish (US)
Pages (from-to)111-119
Number of pages9
JournalPsychiatry Research
Volume47
Issue number2
DOIs
StatePublished - May 1993

Keywords

  • 5-hydroxytryptamine
  • H-lysergic acid diethylamide
  • Suicide attempt

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Fingerprint

Dive into the research topics of 'Serotonin<sub>2</sub> receptor binding in blood platelets of schizophrenic patients'. Together they form a unique fingerprint.

Cite this