SERS Detection of Ricin B-Chain via N-Acetyl-Galactosamine Glycopolymers

Victoria M. Szlag, Matthew J. Styles, Lindsey R. Madison, Antonio R. Campos, Bharat Wagh, Dustin Sprouse, George C. Schatz, Theresa M. Reineke, Christy L. Haynes*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

A novel sensing scheme is exemplified through the detection of ricin B-chain (RBC) in water and liquid food matrices: surface-enhanced Raman spectroscopy (SERS) coupled with an N-acetyl-galactosamine glycopolymer capture layer. The sensing scheme's detection limit was well below that of the predicted oral exposure limit. Theoretical predictions of the normal Raman spectrum of the glycomonomer give insight into polymer-RBC intermolecular interactions.

Original languageEnglish (US)
Pages (from-to)842-846
Number of pages5
JournalACS Sensors
Volume1
Issue number7
DOIs
StatePublished - Jul 22 2016

Keywords

  • DFT modeling
  • film over nanospheres
  • glycopolymers
  • ricin
  • surface-enhanced raman spectroscopy

ASJC Scopus subject areas

  • Bioengineering
  • Instrumentation
  • Process Chemistry and Technology
  • Fluid Flow and Transfer Processes

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