Serum antibodies to LDH-C4

Joyce Shelton; Erwin Goldberg

doi:10.1016/0165-0378(85)90006-3

Serum antibodies to LDH-C₄

Joyce Shelton^*, Erwin Goldberg

^*Corresponding author for this work

Molecular Biosciences

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Human sera from the WHO Reference Bank were tested by a liquid phase radioimmunoassay for antibodies to the sperm-specific form of lactate dehydrogenase (LDH-C₄; LDH-X). Modestly elevated levels of antibodies were detected in about 10% of infertile males and females and in about 20% of vasectomized males, as well as in a few cases in other categories. The occurrence of this anti-LDH-C₄ activity was without overt correlation with other anti-sperm antibody assays. The primary advantage of the radioimmunometric assay is its absolute specificity for a sperm antigen. These findings lend support to contraceptive vaccine development based on LDH-C₄ antigenicity.

Original language	English (US)
Pages (from-to)	321-327
Number of pages	7
Journal	Journal of Reproductive Immunology
Volume	8
Issue number	4
DOIs	https://doi.org/10.1016/0165-0378(85)90006-3
State	Published - Dec 1985

Keywords

LDH-C
antibodies
radioimmunoassay
sperm antigens

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Reproductive Medicine
Obstetrics and Gynecology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0165-0378(85)90006-3

Cite this

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title = "Serum antibodies to LDH-C4",

abstract = "Human sera from the WHO Reference Bank were tested by a liquid phase radioimmunoassay for antibodies to the sperm-specific form of lactate dehydrogenase (LDH-C4; LDH-X). Modestly elevated levels of antibodies were detected in about 10% of infertile males and females and in about 20% of vasectomized males, as well as in a few cases in other categories. The occurrence of this anti-LDH-C4 activity was without overt correlation with other anti-sperm antibody assays. The primary advantage of the radioimmunometric assay is its absolute specificity for a sperm antigen. These findings lend support to contraceptive vaccine development based on LDH-C4 antigenicity.",

keywords = "LDH-C, antibodies, radioimmunoassay, sperm antigens",

author = "Joyce Shelton and Erwin Goldberg",

note = "Funding Information: These studies were supported in part by a grant from the National Institutes of Health (HD05863). Dr. Shelton is the recipient of a National Research Service Award HD06390-01A1. We wish to thank Mrs. Eva Braun and Mrs. Charlene Hendrix for their outstanding technical assistance.",

year = "1985",

month = dec,

doi = "10.1016/0165-0378(85)90006-3",

language = "English (US)",

volume = "8",

pages = "321--327",

journal = "Journal of Reproductive Immunology",

issn = "0165-0378",

publisher = "Elsevier Ireland Ltd",

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T1 - Serum antibodies to LDH-C4

AU - Shelton, Joyce

AU - Goldberg, Erwin

N1 - Funding Information: These studies were supported in part by a grant from the National Institutes of Health (HD05863). Dr. Shelton is the recipient of a National Research Service Award HD06390-01A1. We wish to thank Mrs. Eva Braun and Mrs. Charlene Hendrix for their outstanding technical assistance.

PY - 1985/12

Y1 - 1985/12

N2 - Human sera from the WHO Reference Bank were tested by a liquid phase radioimmunoassay for antibodies to the sperm-specific form of lactate dehydrogenase (LDH-C4; LDH-X). Modestly elevated levels of antibodies were detected in about 10% of infertile males and females and in about 20% of vasectomized males, as well as in a few cases in other categories. The occurrence of this anti-LDH-C4 activity was without overt correlation with other anti-sperm antibody assays. The primary advantage of the radioimmunometric assay is its absolute specificity for a sperm antigen. These findings lend support to contraceptive vaccine development based on LDH-C4 antigenicity.

AB - Human sera from the WHO Reference Bank were tested by a liquid phase radioimmunoassay for antibodies to the sperm-specific form of lactate dehydrogenase (LDH-C4; LDH-X). Modestly elevated levels of antibodies were detected in about 10% of infertile males and females and in about 20% of vasectomized males, as well as in a few cases in other categories. The occurrence of this anti-LDH-C4 activity was without overt correlation with other anti-sperm antibody assays. The primary advantage of the radioimmunometric assay is its absolute specificity for a sperm antigen. These findings lend support to contraceptive vaccine development based on LDH-C4 antigenicity.

KW - LDH-C

KW - antibodies

KW - radioimmunoassay

KW - sperm antigens

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