Serum antibodies to LDH-C4

Joyce Shelton*, Erwin Goldberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Human sera from the WHO Reference Bank were tested by a liquid phase radioimmunoassay for antibodies to the sperm-specific form of lactate dehydrogenase (LDH-C4; LDH-X). Modestly elevated levels of antibodies were detected in about 10% of infertile males and females and in about 20% of vasectomized males, as well as in a few cases in other categories. The occurrence of this anti-LDH-C4 activity was without overt correlation with other anti-sperm antibody assays. The primary advantage of the radioimmunometric assay is its absolute specificity for a sperm antigen. These findings lend support to contraceptive vaccine development based on LDH-C4 antigenicity.

Original languageEnglish (US)
Pages (from-to)321-327
Number of pages7
JournalJournal of Reproductive Immunology
Issue number4
StatePublished - Dec 1985


  • LDH-C
  • antibodies
  • radioimmunoassay
  • sperm antigens

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynecology


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