TY - JOUR
T1 - Serum bupropion levels in 2 breastfeeding mother-infant pairs
AU - Baab, Susan W.
AU - Peindl, Kathleen S.
AU - Piontek, Catherine M.
AU - Wisner, Katherine L.
PY - 2002/10/1
Y1 - 2002/10/1
N2 - Background: These are the first reported data on bupropion and hydroxybupropion levels in infants whose treated mothers were breastfeeding. The information will assist physicians and parents in the risk-benefit decision-making process for bupropion treatment during breastfeeding. Method: Serum samples were obtained by venipuncture from 2 mother-infant pairs. The serum was assayed for levels of bupropion and its most active metabolite, hydroxybupropion. Results: Neither infant had quantifiable serum levels of bupropion or its metabolite at steady state. Neither infant had medical problems during the time of maternal therapy. Conclusion: We recommend obtaining and publishing additional serum level findings for breastfeeding mother-infant pairs since data for bupropion are favorable but limited.
AB - Background: These are the first reported data on bupropion and hydroxybupropion levels in infants whose treated mothers were breastfeeding. The information will assist physicians and parents in the risk-benefit decision-making process for bupropion treatment during breastfeeding. Method: Serum samples were obtained by venipuncture from 2 mother-infant pairs. The serum was assayed for levels of bupropion and its most active metabolite, hydroxybupropion. Results: Neither infant had quantifiable serum levels of bupropion or its metabolite at steady state. Neither infant had medical problems during the time of maternal therapy. Conclusion: We recommend obtaining and publishing additional serum level findings for breastfeeding mother-infant pairs since data for bupropion are favorable but limited.
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U2 - 10.4088/JCP.v63n1008
DO - 10.4088/JCP.v63n1008
M3 - Article
C2 - 12416600
AN - SCOPUS:0036774624
VL - 63
SP - 910
EP - 911
JO - Diseases of the Nervous System
JF - Diseases of the Nervous System
SN - 0160-6689
IS - 10
ER -