Serum cholesterol and cancer in the hypertension detection and follow‐up program

Dexter L. Morris*, Nemat O. Borhani, Edward Fitzsimons, Robert J. Hardy, C. Morton Hawkins, Jess F. Kraus, Darwin R. Labarthe, Leonard Mastbaum, GERALD H. PAYNE, MD ON BEHALF OF THE HYPERTENSION DETECTION AND FOLLOW‐UP PROGRAM COOPERATIVE GROUP

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


The relation between serum cholesterol and cancer incidence was investigated in the population of the Hypertension Detection and Follow‐up Program. During the 5 years of follow‐up, 286 new cancer cases were documented among the 10,940 participants. Overall, age‐adjusted cancer incidence rates, computed by baseline serum cholesterol quartlies, showed a small, but statistically significant, inverse relation between serum cholesterol and cancer incidence. No evidence suggested that the observed relationship was primarily due to confounding by other cancer risk factors, association of low serum cholesterol with incipient but undiagnosed cancer, or problems of competing risks. However, the relationship is weak and a causal interpretation of these immediate results cannot be argued persuasively. Examinations of specific cancer sites and factors related to serum cholesterol are suggested as important lines of research toward clarification of the complex relationships observed.

Original languageEnglish (US)
Pages (from-to)1754-1759
Number of pages6
Issue number9
StatePublished - Nov 1 1983

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Serum cholesterol and cancer in the hypertension detection and follow‐up program'. Together they form a unique fingerprint.

Cite this