TY - JOUR
T1 - Serum cholesterol and cancer in the hypertension detection and follow‐up program
AU - Morris, Dexter L.
AU - Borhani, Nemat O.
AU - Fitzsimons, Edward
AU - Hardy, Robert J.
AU - Hawkins, C. Morton
AU - Kraus, Jess F.
AU - Labarthe, Darwin R.
AU - Mastbaum, Leonard
AU - GERALD H. PAYNE, MD ON BEHALF OF THE HYPERTENSION DETECTION AND FOLLOW‐UP PROGRAM COOPERATIVE GROUP
PY - 1983/11/1
Y1 - 1983/11/1
N2 - The relation between serum cholesterol and cancer incidence was investigated in the population of the Hypertension Detection and Follow‐up Program. During the 5 years of follow‐up, 286 new cancer cases were documented among the 10,940 participants. Overall, age‐adjusted cancer incidence rates, computed by baseline serum cholesterol quartlies, showed a small, but statistically significant, inverse relation between serum cholesterol and cancer incidence. No evidence suggested that the observed relationship was primarily due to confounding by other cancer risk factors, association of low serum cholesterol with incipient but undiagnosed cancer, or problems of competing risks. However, the relationship is weak and a causal interpretation of these immediate results cannot be argued persuasively. Examinations of specific cancer sites and factors related to serum cholesterol are suggested as important lines of research toward clarification of the complex relationships observed.
AB - The relation between serum cholesterol and cancer incidence was investigated in the population of the Hypertension Detection and Follow‐up Program. During the 5 years of follow‐up, 286 new cancer cases were documented among the 10,940 participants. Overall, age‐adjusted cancer incidence rates, computed by baseline serum cholesterol quartlies, showed a small, but statistically significant, inverse relation between serum cholesterol and cancer incidence. No evidence suggested that the observed relationship was primarily due to confounding by other cancer risk factors, association of low serum cholesterol with incipient but undiagnosed cancer, or problems of competing risks. However, the relationship is weak and a causal interpretation of these immediate results cannot be argued persuasively. Examinations of specific cancer sites and factors related to serum cholesterol are suggested as important lines of research toward clarification of the complex relationships observed.
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U2 - 10.1002/1097-0142(19831101)52:9<1754::AID-CNCR2820520933>3.0.CO;2-J
DO - 10.1002/1097-0142(19831101)52:9<1754::AID-CNCR2820520933>3.0.CO;2-J
M3 - Article
C2 - 6616425
AN - SCOPUS:0020599045
SN - 0008-543X
VL - 52
SP - 1754
EP - 1759
JO - cancer
JF - cancer
IS - 9
ER -
