Serum clomipramine and metabolite levels in four nursing mother-infant pairs

K. L. Wisner*, J. M. Perel, J. P. Foglia

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Background: Women with postpartum-onset obsessive compulsive disorder may elect treatment with clomipramine. There is minimal information to guide the clinician who must advise breastfeeding women about clomipramine therapy. Method: Four clomipramine-treated breastfeeding mother-infant pairs were assessed for serum concentrations of clomipramine. N-desmethylclomipramine, and corresponding 8-hydroxymetabolites. Results: Although the mothers exhibited a wide range of serum concentrations, the parent drug and metabolites were either nondetectable or below the quantifiable limit in the sera of all infants. No adverse clinical effects were observed. Conclusion: This report adds to the growing literature that suggests that tricyclic use during breastfeeding rarely results in measurable drug levels in infant sera.

Original languageEnglish (US)
Pages (from-to)17-20
Number of pages4
JournalJournal of Clinical Psychiatry
Issue number1
StatePublished - 1995

ASJC Scopus subject areas

  • Psychiatry and Mental health

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