Serum creatine phosphokinase and aldolase activity in acute schizophrenic patients and their relatives

Herbert Y. Meltzer*, Lester Grinspoon, Richard I. Shader

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Increased activity of cieatine phosphokinase (CPK) or aldolase, or both, was found, on a blind basis, in the serum of 25 of 39 acute schizophrenic patients at some phase of their illness. The median increase in serum enzyme activity was approximately threefold. Smaller increases in serum CPK and aldolase activity were also found in five of 22 first-degree relatives of the acute patients. In the patients, the serum enzyme activity increased briefly and returned to normal but the enzyme increases were persistent in the relatives.

Original languageEnglish (US)
Pages (from-to)552-558
Number of pages7
JournalComprehensive Psychiatry
Volume11
Issue number6
DOIs
StatePublished - Nov 1970

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

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