SUBSTANTIAL increases in serum creatinine phosphokinase (CPK) and aldolase activities occur in many acutely psychotic patients1-3. Futher investigation has shown a frequent but not invariant relationship between sleep disturbance and the serum CPK (and aldolase) activity in acutely psychotic patients4. In eight acutely psychotic patients, severe sleep disruption, often amounting to total insomnia with particular reductions in rapid eye movement (REM) sleep5, was associated with high serum CPK activity. We now report that elevated serum CPK activity and aldolase activity occur in normal subjects during and after experimental sleep deprivation, though many characteristics of these increases in enzyme activity are different from those in acutely psychotic patients.
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