TY - JOUR
T1 - Serum high-sensitivity c-reactive protein and heat shock protein 27 antibody titers in patients with stroke and 6-month prognosis
AU - Azarpazhooh, Mahmoud Reza
AU - Mobarra, Naser
AU - Parizadeh, Syyed Mohammad Reza
AU - Tavallaie, Shima
AU - Bagheri, Mahsa
AU - Rahsepar, Amir Ali
AU - Ghayour-Mobarhan, Majid
AU - Sahebkar, Amirhossein
AU - Ferns, Gordon A.A.
PY - 2010/8
Y1 - 2010/8
N2 - Serum heat shock protein 27 immunoglobulin G (IgG) antibody titers (anti-HSP27) and high-sensitivity C-reactive protein (hsCRP) concentrations were measured in samples from 168 patients in the first 24 hours after the onset of stroke and 80 age-and sex-matched control participants. In patients with stroke, median serum anti-HSP27 titer was significantly higher than that of the control group (0.18 [0.14-0.28] vs 0.08 [0.04-0.12], P <.001). Median serum hsCRP concentration was also significantly higher in patients compared with the control group (11.43 [8.07-13.53] vs 3.23 [1.66-6.24], P <.001). Serum anti-HSP27 and hsCRP concentrations did not differ significantly among patients with different stroke types. Neither serum anti-HSP27 nor hsCRP levels predicted 6-month prognosis in the patients with stroke. We conclude that serum anti-HSP27 titers and hsCRP concentrations are elevated in patients with stroke but do not distinguish between stroke types or predict 6-month prognosis.
AB - Serum heat shock protein 27 immunoglobulin G (IgG) antibody titers (anti-HSP27) and high-sensitivity C-reactive protein (hsCRP) concentrations were measured in samples from 168 patients in the first 24 hours after the onset of stroke and 80 age-and sex-matched control participants. In patients with stroke, median serum anti-HSP27 titer was significantly higher than that of the control group (0.18 [0.14-0.28] vs 0.08 [0.04-0.12], P <.001). Median serum hsCRP concentration was also significantly higher in patients compared with the control group (11.43 [8.07-13.53] vs 3.23 [1.66-6.24], P <.001). Serum anti-HSP27 and hsCRP concentrations did not differ significantly among patients with different stroke types. Neither serum anti-HSP27 nor hsCRP levels predicted 6-month prognosis in the patients with stroke. We conclude that serum anti-HSP27 titers and hsCRP concentrations are elevated in patients with stroke but do not distinguish between stroke types or predict 6-month prognosis.
KW - antibody
KW - heat shock protein 27
KW - high sensitive C-reactive protein
KW - stroke
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U2 - 10.1177/0003319709360524
DO - 10.1177/0003319709360524
M3 - Article
C2 - 20150172
AN - SCOPUS:77955044120
SN - 0003-3197
VL - 61
SP - 607
EP - 612
JO - Angiology
JF - Angiology
IS - 6
ER -