Serum IGF-I and C-reactive protein in healthy black and white young men: The CARDIA male hormone study

Laura A. Colangelo*, Brian Chiu, Peter Kopp, Kiang Liu, Susan M. Gapstur

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Objective: Animal and human studies suggest that C-reactive protein (CRP) may be inversely associated with serum insulin-like growth factor-I (IGF-I) concentrations. However, most human studies have not controlled adequately for confounding factors, particularly nutritional intake. This population-based study examined whether CRP is inversely associated with IGF-I and IGFBP-3 concentrations. Methods: In cross-sectional analysis, multivariable linear regression with adjustment for age, BMI, smoking status, alcohol intake, and nutritional factors was used to relate log CRP, the independent variable, to IGF-I and IGFBP-3 in a sample of black (n = 364) and white men (n = 486) separately by race. Results: Only black men had positive findings: log CRP was significantly associated with IGF-I (β = -13.1 ng/ml, p = 0.02) and the difference in mean IGF-I concentrations between the highest and lowest quartiles of CRP was 26 ng/ml. There was a statistically significant interaction between log CRP and smoking status (p = 0.02); the regression coefficient for IGF-I predicted from log CRP was significant in smokers (β = -39.8 ng/ml, p = 0.0001), but not in non-smokers. The difference in mean IGF-I concentrations between highest and lowest quartiles of CRP was 100 ng/ml for black smokers. There were no associations for IGFBP-3. Conclusions: In our study, CRP levels are inversely associated with IGF-I concentrations in black male smokers; however, the causal nature of the association is unclear and should be studied further.

Original languageEnglish (US)
Pages (from-to)420-425
Number of pages6
JournalGrowth Hormone and IGF Research
Volume19
Issue number5
DOIs
StatePublished - Oct 2009

Keywords

  • C-reactive protein
  • Insulin-like growth factor binding protein-3
  • Insulin-like growth factor-I
  • Men

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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