TY - JOUR
T1 - Serum IGF-I and C-reactive protein in healthy black and white young men
T2 - The CARDIA male hormone study
AU - Colangelo, Laura A.
AU - Chiu, Brian
AU - Kopp, Peter
AU - Liu, Kiang
AU - Gapstur, Susan M.
N1 - Funding Information:
This research was supported by U.S. Public Health Service grant RO1-CA770403 from the National Cancer Institute and U.S. Public Health Service contracts NO1-HC-48047, NO1-HC-48048, NO1-HC-48049, NO1-HC-48050, and NO1-HC-95095 from the National Heart, Lung, and Blood Institute. The authors had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
PY - 2009/10
Y1 - 2009/10
N2 - Objective: Animal and human studies suggest that C-reactive protein (CRP) may be inversely associated with serum insulin-like growth factor-I (IGF-I) concentrations. However, most human studies have not controlled adequately for confounding factors, particularly nutritional intake. This population-based study examined whether CRP is inversely associated with IGF-I and IGFBP-3 concentrations. Methods: In cross-sectional analysis, multivariable linear regression with adjustment for age, BMI, smoking status, alcohol intake, and nutritional factors was used to relate log CRP, the independent variable, to IGF-I and IGFBP-3 in a sample of black (n = 364) and white men (n = 486) separately by race. Results: Only black men had positive findings: log CRP was significantly associated with IGF-I (β = -13.1 ng/ml, p = 0.02) and the difference in mean IGF-I concentrations between the highest and lowest quartiles of CRP was 26 ng/ml. There was a statistically significant interaction between log CRP and smoking status (p = 0.02); the regression coefficient for IGF-I predicted from log CRP was significant in smokers (β = -39.8 ng/ml, p = 0.0001), but not in non-smokers. The difference in mean IGF-I concentrations between highest and lowest quartiles of CRP was 100 ng/ml for black smokers. There were no associations for IGFBP-3. Conclusions: In our study, CRP levels are inversely associated with IGF-I concentrations in black male smokers; however, the causal nature of the association is unclear and should be studied further.
AB - Objective: Animal and human studies suggest that C-reactive protein (CRP) may be inversely associated with serum insulin-like growth factor-I (IGF-I) concentrations. However, most human studies have not controlled adequately for confounding factors, particularly nutritional intake. This population-based study examined whether CRP is inversely associated with IGF-I and IGFBP-3 concentrations. Methods: In cross-sectional analysis, multivariable linear regression with adjustment for age, BMI, smoking status, alcohol intake, and nutritional factors was used to relate log CRP, the independent variable, to IGF-I and IGFBP-3 in a sample of black (n = 364) and white men (n = 486) separately by race. Results: Only black men had positive findings: log CRP was significantly associated with IGF-I (β = -13.1 ng/ml, p = 0.02) and the difference in mean IGF-I concentrations between the highest and lowest quartiles of CRP was 26 ng/ml. There was a statistically significant interaction between log CRP and smoking status (p = 0.02); the regression coefficient for IGF-I predicted from log CRP was significant in smokers (β = -39.8 ng/ml, p = 0.0001), but not in non-smokers. The difference in mean IGF-I concentrations between highest and lowest quartiles of CRP was 100 ng/ml for black smokers. There were no associations for IGFBP-3. Conclusions: In our study, CRP levels are inversely associated with IGF-I concentrations in black male smokers; however, the causal nature of the association is unclear and should be studied further.
KW - C-reactive protein
KW - Insulin-like growth factor binding protein-3
KW - Insulin-like growth factor-I
KW - Men
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U2 - 10.1016/j.ghir.2008.12.002
DO - 10.1016/j.ghir.2008.12.002
M3 - Article
C2 - 19138871
AN - SCOPUS:70349345810
VL - 19
SP - 420
EP - 425
JO - Growth Hormone and IGF Research
JF - Growth Hormone and IGF Research
SN - 1096-6374
IS - 5
ER -