Serum inflammatory and immune marker response after bare-metal or drug-eluting stent implantation following percutaneous coronary intervention

Mohsen Moohebati; Homa Falsoleiman; Mashalla Dehghani; Afsoon Fazlinezhad; Mehdi Hassanzadeh Daloee; Habib Esmaeili; Seyyed Mohammad Reza Parizadeh; Shima Tavallaie; Amir Ali Rahsepar; Roghayeh Paydar; Seyyed Mohammad Reza Kazemi-Bajestani; Hossein Pourghadam-Yari; Mina Akbari Rad; Talat Zoghdar-Moghadam; Majid Ghayour-Mobarhan; Gordon A. Ferns

doi:10.1177/0003319710375086

Serum inflammatory and immune marker response after bare-metal or drug-eluting stent implantation following percutaneous coronary intervention

Mohsen Moohebati, Homa Falsoleiman, Mashalla Dehghani, Afsoon Fazlinezhad, Mehdi Hassanzadeh Daloee, Habib Esmaeili, Seyyed Mohammad Reza Parizadeh, Shima Tavallaie, Amir Ali Rahsepar, Roghayeh Paydar, Seyyed Mohammad Reza Kazemi-Bajestani, Hossein Pourghadam-Yari, Mina Akbari Rad, Talat Zoghdar-Moghadam, Majid Ghayour-Mobarhan^*, Gordon A. Ferns

^*Corresponding author for this work

Radiology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We assessed the changes in serum antiheat shock protein (HSP)-27 antibody and high-sensitivity C-reactive protein (hsCRP) levels, following the placement of a drug-eluting stent (DES) or bare-metal stent (BMS) in patients with stable coronary artery disease. Either a BMS or DES was implanted in 137 patients (82 BMS; 55 DES). Anti-HSP27 and hsCRP levels were measured 24 hours before and 24 hours after stenting. Median hsCRP serum levels increased significantly to 60.78 (10.13-84.87) and 77.80 (50.00-84.84) mg/L for BMS and DES groups (P =.006 and P =.000, respectively); this increase did not differ significantly between the 2 groups. Median anti-HSP27 antibody levels decreased to 0.26 (0.17-0.49) and 0.21 (0.16-0.29) absorbency units in BMS and DES groups (P =.045 and P = < 0.001, respectively). The changes in anti-HSP27 antibody titers were significant between the 2 groups (P =.015). Bare-metal stent and DES differ in stimulation of immune rather than inflammatory responses. Less stent restenosis after DES compared with BMS implantation could, in part, be attributed to differences in immune responses.

Original language	English (US)
Pages (from-to)	184-190
Number of pages	7
Journal	Angiology
Volume	62
Issue number	2
DOIs	https://doi.org/10.1177/0003319710375086
State	Published - Feb 2011

Keywords

bare-metal stent
drug-eluting stent
heat shock protein 27
high-sensitivity C-reactive protein
percutaneous coronary intervention

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1177/0003319710375086

Cite this

Moohebati, M., Falsoleiman, H., Dehghani, M., Fazlinezhad, A., Daloee, M. H., Esmaeili, H., Parizadeh, S. M. R., Tavallaie, S., Rahsepar, A. A., Paydar, R., Kazemi-Bajestani, S. M. R., Pourghadam-Yari, H., Rad, M. A., Zoghdar-Moghadam, T., Ghayour-Mobarhan, M., & Ferns, G. A. (2011). Serum inflammatory and immune marker response after bare-metal or drug-eluting stent implantation following percutaneous coronary intervention. Angiology, 62(2), 184-190. https://doi.org/10.1177/0003319710375086

@article{2c0e2bdd6ee948dda8ab5cfcbef553cf,

title = "Serum inflammatory and immune marker response after bare-metal or drug-eluting stent implantation following percutaneous coronary intervention",

abstract = "We assessed the changes in serum antiheat shock protein (HSP)-27 antibody and high-sensitivity C-reactive protein (hsCRP) levels, following the placement of a drug-eluting stent (DES) or bare-metal stent (BMS) in patients with stable coronary artery disease. Either a BMS or DES was implanted in 137 patients (82 BMS; 55 DES). Anti-HSP27 and hsCRP levels were measured 24 hours before and 24 hours after stenting. Median hsCRP serum levels increased significantly to 60.78 (10.13-84.87) and 77.80 (50.00-84.84) mg/L for BMS and DES groups (P =.006 and P =.000, respectively); this increase did not differ significantly between the 2 groups. Median anti-HSP27 antibody levels decreased to 0.26 (0.17-0.49) and 0.21 (0.16-0.29) absorbency units in BMS and DES groups (P =.045 and P = < 0.001, respectively). The changes in anti-HSP27 antibody titers were significant between the 2 groups (P =.015). Bare-metal stent and DES differ in stimulation of immune rather than inflammatory responses. Less stent restenosis after DES compared with BMS implantation could, in part, be attributed to differences in immune responses.",

keywords = "bare-metal stent, drug-eluting stent, heat shock protein 27, high-sensitivity C-reactive protein, percutaneous coronary intervention",

author = "Mohsen Moohebati and Homa Falsoleiman and Mashalla Dehghani and Afsoon Fazlinezhad and Daloee, \{Mehdi Hassanzadeh\} and Habib Esmaeili and Parizadeh, \{Seyyed Mohammad Reza\} and Shima Tavallaie and Rahsepar, \{Amir Ali\} and Roghayeh Paydar and Kazemi-Bajestani, \{Seyyed Mohammad Reza\} and Hossein Pourghadam-Yari and Rad, \{Mina Akbari\} and Talat Zoghdar-Moghadam and Majid Ghayour-Mobarhan and Ferns, \{Gordon A.\}",

year = "2011",

month = feb,

doi = "10.1177/0003319710375086",

language = "English (US)",

volume = "62",

pages = "184--190",

journal = "Angiology",

issn = "0003-3197",

publisher = "Elsevier Masson",

number = "2",

}

Moohebati, M, Falsoleiman, H, Dehghani, M, Fazlinezhad, A, Daloee, MH, Esmaeili, H, Parizadeh, SMR, Tavallaie, S, Rahsepar, AA, Paydar, R, Kazemi-Bajestani, SMR, Pourghadam-Yari, H, Rad, MA, Zoghdar-Moghadam, T, Ghayour-Mobarhan, M & Ferns, GA 2011, 'Serum inflammatory and immune marker response after bare-metal or drug-eluting stent implantation following percutaneous coronary intervention', Angiology, vol. 62, no. 2, pp. 184-190. https://doi.org/10.1177/0003319710375086

TY - JOUR

T1 - Serum inflammatory and immune marker response after bare-metal or drug-eluting stent implantation following percutaneous coronary intervention

AU - Moohebati, Mohsen

AU - Falsoleiman, Homa

AU - Dehghani, Mashalla

AU - Fazlinezhad, Afsoon

AU - Daloee, Mehdi Hassanzadeh

AU - Esmaeili, Habib

AU - Parizadeh, Seyyed Mohammad Reza

AU - Tavallaie, Shima

AU - Rahsepar, Amir Ali

AU - Paydar, Roghayeh

AU - Kazemi-Bajestani, Seyyed Mohammad Reza

AU - Pourghadam-Yari, Hossein

AU - Rad, Mina Akbari

AU - Zoghdar-Moghadam, Talat

AU - Ghayour-Mobarhan, Majid

AU - Ferns, Gordon A.

PY - 2011/2

Y1 - 2011/2

N2 - We assessed the changes in serum antiheat shock protein (HSP)-27 antibody and high-sensitivity C-reactive protein (hsCRP) levels, following the placement of a drug-eluting stent (DES) or bare-metal stent (BMS) in patients with stable coronary artery disease. Either a BMS or DES was implanted in 137 patients (82 BMS; 55 DES). Anti-HSP27 and hsCRP levels were measured 24 hours before and 24 hours after stenting. Median hsCRP serum levels increased significantly to 60.78 (10.13-84.87) and 77.80 (50.00-84.84) mg/L for BMS and DES groups (P =.006 and P =.000, respectively); this increase did not differ significantly between the 2 groups. Median anti-HSP27 antibody levels decreased to 0.26 (0.17-0.49) and 0.21 (0.16-0.29) absorbency units in BMS and DES groups (P =.045 and P = < 0.001, respectively). The changes in anti-HSP27 antibody titers were significant between the 2 groups (P =.015). Bare-metal stent and DES differ in stimulation of immune rather than inflammatory responses. Less stent restenosis after DES compared with BMS implantation could, in part, be attributed to differences in immune responses.

AB - We assessed the changes in serum antiheat shock protein (HSP)-27 antibody and high-sensitivity C-reactive protein (hsCRP) levels, following the placement of a drug-eluting stent (DES) or bare-metal stent (BMS) in patients with stable coronary artery disease. Either a BMS or DES was implanted in 137 patients (82 BMS; 55 DES). Anti-HSP27 and hsCRP levels were measured 24 hours before and 24 hours after stenting. Median hsCRP serum levels increased significantly to 60.78 (10.13-84.87) and 77.80 (50.00-84.84) mg/L for BMS and DES groups (P =.006 and P =.000, respectively); this increase did not differ significantly between the 2 groups. Median anti-HSP27 antibody levels decreased to 0.26 (0.17-0.49) and 0.21 (0.16-0.29) absorbency units in BMS and DES groups (P =.045 and P = < 0.001, respectively). The changes in anti-HSP27 antibody titers were significant between the 2 groups (P =.015). Bare-metal stent and DES differ in stimulation of immune rather than inflammatory responses. Less stent restenosis after DES compared with BMS implantation could, in part, be attributed to differences in immune responses.

KW - bare-metal stent

KW - drug-eluting stent

KW - heat shock protein 27

KW - high-sensitivity C-reactive protein

KW - percutaneous coronary intervention

UR - https://www.scopus.com/pages/publications/78651403747

UR - https://www.scopus.com/inward/citedby.url?scp=78651403747&partnerID=8YFLogxK

U2 - 10.1177/0003319710375086

DO - 10.1177/0003319710375086

M3 - Article

C2 - 20713488

AN - SCOPUS:78651403747

SN - 0003-3197

VL - 62

SP - 184

EP - 190

JO - Angiology

JF - Angiology

IS - 2

ER -

Serum inflammatory and immune marker response after bare-metal or drug-eluting stent implantation following percutaneous coronary intervention

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this