TY - JOUR
T1 - Serum keratan sulfate levels in osteoarthritis patients
AU - Sweet, M. Barry E
AU - Coelho, Angelina
AU - Schnitzler, Christine M.
AU - Schnitzer, Thomas J.
AU - Lenz, Mary Ellen
AU - Jakim, Itzhak
AU - Kuettner, Klaus E.
AU - Thonar, EUGENE J ‐M A
PY - 1988/5
Y1 - 1988/5
N2 - Serum levels of keratan sulfate (KS), measured by an enzyme‐linked immunosorbent–inhibition assay, were found to be significantly higher in 31 patients with hypertrophic osteoarthritis (OA) than those in 41 adults without joint disease. Seventy‐seven percent of patients with OA, but only 12% of control subjects, had serum levels which were more than 1 SD above the mean of the control group. Following replacement of a single osteoarthritic hip joint, serum KS levels decreased, at first, in all patients. Subsequently, the concentration of serum KS progressively increased; 6 months following surgery, KS levels were similar or close to the preoperative levels in virtually all patients. The results suggest that patients with hypertrophic OA may have a generalized imbalance of cartilage proteoglycan metabolism. Measurements of serum KS are likely to prove most useful in studying this particular subset of patients with generalized OA.
AB - Serum levels of keratan sulfate (KS), measured by an enzyme‐linked immunosorbent–inhibition assay, were found to be significantly higher in 31 patients with hypertrophic osteoarthritis (OA) than those in 41 adults without joint disease. Seventy‐seven percent of patients with OA, but only 12% of control subjects, had serum levels which were more than 1 SD above the mean of the control group. Following replacement of a single osteoarthritic hip joint, serum KS levels decreased, at first, in all patients. Subsequently, the concentration of serum KS progressively increased; 6 months following surgery, KS levels were similar or close to the preoperative levels in virtually all patients. The results suggest that patients with hypertrophic OA may have a generalized imbalance of cartilage proteoglycan metabolism. Measurements of serum KS are likely to prove most useful in studying this particular subset of patients with generalized OA.
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U2 - 10.1002/art.1780310510
DO - 10.1002/art.1780310510
M3 - Article
C2 - 2967706
AN - SCOPUS:0023909228
SN - 0004-3591
VL - 31
SP - 648
EP - 652
JO - Arthritis & Rheumatism
JF - Arthritis & Rheumatism
IS - 5
ER -