TY - JOUR
T1 - Serum lactate as a potential biomarker of malignancy in primary adult brain tumours
AU - Mariappan, Ramamani
AU - Venkatraghavan, Lashmi
AU - Vertanian, Alenoush
AU - Agnihotri, Sameer
AU - Cynthia, Shalini
AU - Reyhani, Sareh
AU - Tung, Takyee
AU - Khan, Osaama H.
AU - Zadeh, Gelareh
N1 - Publisher Copyright:
© 2014 Elsevier Ltd. All rights reserved.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Lactate, a by-product of glycolysis, is an indicator of poor tissue perfusion and is a useful biomarker with prognostic value in risk-stratifying patients in several diseases. Furthermore, elevated lactate production is observed in tumour glycolysis, also known as the Warburg effect, and is essential in promoting tumour cell invasion, metastasis, and immune system evasion, promoting resistance to cell death. However, there are no studies of elevated serum lactate in brain tumour patients as a potential biomarker, to our knowledge. The aim of this study is to determine possible correlations between the malignancy of tumours and pre- and intraoperative serum lactate elevation in patients undergoing craniotomy for tumour resection. We provide initial evidence that a rise in serum lactate can be used as a non-invasive biomarker that correlates with brain tumour grade. The results from this study and future prospective studies may allow for determination of tumour progression and response to therapy using serum lactate as a biomarker.
AB - Lactate, a by-product of glycolysis, is an indicator of poor tissue perfusion and is a useful biomarker with prognostic value in risk-stratifying patients in several diseases. Furthermore, elevated lactate production is observed in tumour glycolysis, also known as the Warburg effect, and is essential in promoting tumour cell invasion, metastasis, and immune system evasion, promoting resistance to cell death. However, there are no studies of elevated serum lactate in brain tumour patients as a potential biomarker, to our knowledge. The aim of this study is to determine possible correlations between the malignancy of tumours and pre- and intraoperative serum lactate elevation in patients undergoing craniotomy for tumour resection. We provide initial evidence that a rise in serum lactate can be used as a non-invasive biomarker that correlates with brain tumour grade. The results from this study and future prospective studies may allow for determination of tumour progression and response to therapy using serum lactate as a biomarker.
KW - Biomarker
KW - Glioblastoma multiforme
KW - Lactate
KW - Serum
KW - Tumour glycolysis
KW - Warburg effect
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U2 - 10.1016/j.jocn.2014.06.005
DO - 10.1016/j.jocn.2014.06.005
M3 - Article
C2 - 25172017
AN - SCOPUS:84920698850
VL - 22
SP - 144
EP - 148
JO - Journal of Clinical Neuroscience
JF - Journal of Clinical Neuroscience
SN - 0967-5868
IS - 1
ER -