Serum leptin and total dietary energy intake: The INTERLIPID Study

Yasuyuki Nakamura*, Hirotsugu Ueshima, Nagako Okuda, Yoshitaka Murakami, Katsuyuki Miura, Yoshikuni Kita, Tomonori Okamura, Akira Okayama, Tanvir C. Turin, Sohel R. Choudhry, Beatriz Rodriguez, J. David Curb, Jeremiah Stamler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Purpose: It has been hypothesized that leptin-induced appetite suppression is impaired in obese individuals, but little human evidence is available documenting this. We investigated relations between serum leptin and total energy intake using INTERLIPID/INTERMAP data on Japanese-Americans in Hawaii and Japanese in Japan. Methods: Serum leptin and nutrient intakes were examined by standardized methods in men and women aged 40-59 years from two population samples, one Japanese-American in Hawaii (88 men, 94 women), the other Japanese in central Japan (123 men, 111 women). Multiple linear regression analyses stratified by BMI category (<25 kg/m2, 25-29.9 kg/m2, and ≥30 kg/m2) with adjustment for possible confounders were used to examine the relation between log-leptin and total dietary energy intake. Results: In multivariate regression analyses, in those with BMI < 25 kg/m2 and in those with BMI between 25 and 29.9 kg/m2, log-leptin was not significantly related to total dietary energy intake; in those with BMI ≥ 30 kg/m2, it was significantly inversely related to total dietary energy intake (P = 0.029), independent of body weight and physical activity. Physical activity score was significantly positively related to total dietary energy intake only in participants with BMI < 25 kg/m 2 (P < 0.001). Conclusion: Leptin was significantly inversely associated with dietary energy intake in obese persons, but not in overweight and normal-weight persons.

Original languageEnglish (US)
Pages (from-to)1641-1648
Number of pages8
JournalEuropean Journal of Nutrition
Issue number6
StatePublished - Sep 2013


  • Body mass
  • Japanese in Japan and Hawaii
  • Leptin
  • Obesity
  • Population study
  • Total energy intake

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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