Serum macrophage colony-stimulating factor (M-CSF) levels correlate with clinical response to interferon-alpha in patients with early-stage B-CLL

A. P. Jewell*, K. L. Yong, C. P. Worman, C. P. Tsakona, F. J. Giles, A. H. Goldstone

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Interferon-alpha (IFN-α) reduces peripheral lymphocyte counts in B-CLL (CLL). In eight patients with stage 0 CLL on IFN-α therapy, peripheral lymphocyte counts fell to 61.7 ± 19.5% of baseline at week 2 (P < 0.01), while serum M-CSF levels rose from 455 ± 183 U/ml to 686 ± 110 U/ml (P < 0.05). Neopterin levels also showed a significant rise. M-CSF levels were correlated with clinical response in these patients. Increased production of M-CSF and the activation of mononuclear phagocytes may be involved in clinical responses to IFN-α in early-stage CLL.

Original languageEnglish (US)
Pages (from-to)441-443
Number of pages3
JournalBritish Journal of Haematology
Volume86
Issue number2
DOIs
StatePublished - Jan 1 1994

Keywords

  • CLL
  • IFN-α
  • M-CSF
  • serum

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Serum macrophage colony-stimulating factor (M-CSF) levels correlate with clinical response to interferon-alpha in patients with early-stage B-CLL'. Together they form a unique fingerprint.

  • Cite this