Serum matrix metalloproteinase levels correlate with brain injury in human immunodeficiency virus infection

Ann B. Ragin; Ying Wu; Renee Ochs; Rachel Scheidegger; Bruce A. Cohen; Justin C. McArthur; Leon G. Epstein; Katherine Conant

doi:10.1080/13550280902913271

Serum matrix metalloproteinase levels correlate with brain injury in human immunodeficiency virus infection

Ann B. Ragin, Ying Wu, Renee Ochs, Rachel Scheidegger, Bruce A. Cohen, Justin C. McArthur, Leon G. Epstein, Katherine Conant

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Circulating levels of specific matrix metalloproteinases (MMPs; 1 and 7) were evaluated as correlates of brain injury in eight individuals in advanced human immunodeficiency virus (HIV) infection. Neurological status was quantified in vivo with automated segmentation algorithms and with diffusion tensor imaging. Both metalloproteinases correlated with microstructural brain alterations and the degree of atrophy. MMPs may influence neurological outcome through involvement in neuroimmune response, blood-brain barrier permeability, leukocyte migration, and MMP-mediated neurotoxicity.

Original language	English (US)
Pages (from-to)	275-281
Number of pages	7
Journal	Journal of neurovirology
Volume	15
Issue number	3
DOIs	https://doi.org/10.1080/13550280902913271
State	Published - 2009

Funding

This work was supported by National Institutes of Health grants MH66705 (A.B.R.), MH080636 (A.B.R.), NS052580 (K.C.), and MH075673 (J.C.M.). The NEAD cohort was supported by NS044807 (J.C.M.) and NS049465 (J.C.M.).

Keywords

DTI
HIV dementia
MMP-1
MMP-7
NeuroAIDS
Segmentation

ASJC Scopus subject areas

Clinical Neurology
Neurology
Cellular and Molecular Neuroscience
Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/13550280902913271

Cite this

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title = "Serum matrix metalloproteinase levels correlate with brain injury in human immunodeficiency virus infection",

abstract = "Circulating levels of specific matrix metalloproteinases (MMPs; 1 and 7) were evaluated as correlates of brain injury in eight individuals in advanced human immunodeficiency virus (HIV) infection. Neurological status was quantified in vivo with automated segmentation algorithms and with diffusion tensor imaging. Both metalloproteinases correlated with microstructural brain alterations and the degree of atrophy. MMPs may influence neurological outcome through involvement in neuroimmune response, blood-brain barrier permeability, leukocyte migration, and MMP-mediated neurotoxicity.",

keywords = "DTI, HIV dementia, MMP-1, MMP-7, NeuroAIDS, Segmentation",

author = "Ragin, {Ann B.} and Ying Wu and Renee Ochs and Rachel Scheidegger and Cohen, {Bruce A.} and McArthur, {Justin C.} and Epstein, {Leon G.} and Katherine Conant",

note = "Funding Information: This work was supported by National Institutes of Health grants MH66705 (A.B.R.), MH080636 (A.B.R.), NS052580 (K.C.), and MH075673 (J.C.M.). The NEAD cohort was supported by NS044807 (J.C.M.) and NS049465 (J.C.M.).",

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AU - Ragin, Ann B.

AU - Wu, Ying

AU - Ochs, Renee

AU - Scheidegger, Rachel

AU - Cohen, Bruce A.

AU - McArthur, Justin C.

AU - Epstein, Leon G.

AU - Conant, Katherine

N1 - Funding Information: This work was supported by National Institutes of Health grants MH66705 (A.B.R.), MH080636 (A.B.R.), NS052580 (K.C.), and MH075673 (J.C.M.). The NEAD cohort was supported by NS044807 (J.C.M.) and NS049465 (J.C.M.).

PY - 2009

Y1 - 2009

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AB - Circulating levels of specific matrix metalloproteinases (MMPs; 1 and 7) were evaluated as correlates of brain injury in eight individuals in advanced human immunodeficiency virus (HIV) infection. Neurological status was quantified in vivo with automated segmentation algorithms and with diffusion tensor imaging. Both metalloproteinases correlated with microstructural brain alterations and the degree of atrophy. MMPs may influence neurological outcome through involvement in neuroimmune response, blood-brain barrier permeability, leukocyte migration, and MMP-mediated neurotoxicity.

KW - DTI

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KW - MMP-1

KW - MMP-7

KW - NeuroAIDS

KW - Segmentation

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Serum matrix metalloproteinase levels correlate with brain injury in human immunodeficiency virus infection

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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