Serum matrix metalloproteinase levels correlate with brain injury in human immunodeficiency virus infection

Ann B. Ragin, Ying Wu, Renee Ochs, Rachel Scheidegger, Bruce A. Cohen, Justin C. McArthur, Leon G. Epstein, Katherine Conant

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Circulating levels of specific matrix metalloproteinases (MMPs; 1 and 7) were evaluated as correlates of brain injury in eight individuals in advanced human immunodeficiency virus (HIV) infection. Neurological status was quantified in vivo with automated segmentation algorithms and with diffusion tensor imaging. Both metalloproteinases correlated with microstructural brain alterations and the degree of atrophy. MMPs may influence neurological outcome through involvement in neuroimmune response, blood-brain barrier permeability, leukocyte migration, and MMP-mediated neurotoxicity.

Original languageEnglish (US)
Pages (from-to)275-281
Number of pages7
JournalJournal of neurovirology
Volume15
Issue number3
DOIs
StatePublished - 2009

Keywords

  • DTI
  • HIV dementia
  • MMP-1
  • MMP-7
  • NeuroAIDS
  • Segmentation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

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