Serum microRNA profiling in patients with glioblastoma: A survival analysis

Hua Zhao*, Jie Shen, Tiffany R. Hodges, Renduo Song, Gregory N. Fuller, Amy B. Heimberger

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review

40 Scopus citations


Because circulating microRNAs (miRNAs) have drawn a great deal of attention as promising novel cancer diagnostics and prognostic biomarkers, we sought to identify serum miRNAs significantly associated with outcome in glioblastoma patients. To do this, we performed global miRNA profiling in serum samples from 106 primary glioblastoma patients. The study subjects were randomly divided into two sets: set one (n = 40) and set two (n = 66). Using a Cox regression model, 3 serum miRNAs (miR-106a-5p, miR-182, and miR-145-5p) and 5 serum miRNAs (miR-222-3p, miR-182, miR-20a-5p, miR-106a-5p, and miR-145-5p) were identified significantly associated with 2-year patient overall survival and disease-free survival (P < 0.05) in both sets and the combined set. We then created the miRNA risk scores to assess the total impact of the significant serum miRNAs on survival. The high risk scores were associated with poor patient survival (overall survival: HR = 1.92, 95% CI: 1.19, 10.23, and disease-free survival: HR = 2.03, 95%CI: 1.24, 4.28), and were independent of other clinicopathological factors. Our results suggest that serum miRNAs could serve as prognostic predictors of glioblastoma.

Original languageEnglish (US)
Article number59
JournalMolecular Cancer
Issue number1
StatePublished - Mar 11 2017
Externally publishedYes


  • And prognosis
  • Glioblastoma
  • Serum microRNAs

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Cancer Research


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