Serum nifedipine concentrations and response of patients with pulmonary hypertension

Bradley G. Phillips; Jerry L. Bauman; Marieke D. Schoen; Timothy J. Hoon; Bruce J. Schrader; Stuart Rich

doi:10.1016/S0002-9149(96)00037-9

Serum nifedipine concentrations and response of patients with pulmonary hypertension

Bradley G. Phillips, Jerry L. Bauman^*, Marieke D. Schoen, Timothy J. Hoon, Bruce J. Schrader, Stuart Rich

^*Corresponding author for this work

Medicine, Cardiology Division

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

In patients with primary pulmonary hypertension who respond to nifedipine during acute drug testing, there is a significant linear correlation of serum nifedipine concentration with pulmonary artery pressure and resistance. Although most demonstrate an initial response at readily attainable nifedipine concentrations with conventional dosages, a subset of patients seem to display delayed or incomplete oral absorption; these results may facilitate the clinical use of nifedipine in patients with primary pulmonary hypertension.

Original language	English (US)
Pages (from-to)	996-999
Number of pages	4
Journal	American Journal of Cardiology
Volume	77
Issue number	11
DOIs	https://doi.org/10.1016/S0002-9149(96)00037-9
State	Published - May 1 1996

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/S0002-9149(96)00037-9

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abstract = "In patients with primary pulmonary hypertension who respond to nifedipine during acute drug testing, there is a significant linear correlation of serum nifedipine concentration with pulmonary artery pressure and resistance. Although most demonstrate an initial response at readily attainable nifedipine concentrations with conventional dosages, a subset of patients seem to display delayed or incomplete oral absorption; these results may facilitate the clinical use of nifedipine in patients with primary pulmonary hypertension.",

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AU - Bauman, Jerry L.

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AU - Hoon, Timothy J.

AU - Schrader, Bruce J.

AU - Rich, Stuart

PY - 1996/5/1

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AB - In patients with primary pulmonary hypertension who respond to nifedipine during acute drug testing, there is a significant linear correlation of serum nifedipine concentration with pulmonary artery pressure and resistance. Although most demonstrate an initial response at readily attainable nifedipine concentrations with conventional dosages, a subset of patients seem to display delayed or incomplete oral absorption; these results may facilitate the clinical use of nifedipine in patients with primary pulmonary hypertension.

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Serum nifedipine concentrations and response of patients with pulmonary hypertension

Abstract

ASJC Scopus subject areas

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