Serum nifedipine concentrations and response of patients with pulmonary hypertension

Bradley G. Phillips, Jerry L. Bauman*, Marieke D. Schoen, Timothy J. Hoon, Bruce J. Schrader, Stuart Rich

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

In patients with primary pulmonary hypertension who respond to nifedipine during acute drug testing, there is a significant linear correlation of serum nifedipine concentration with pulmonary artery pressure and resistance. Although most demonstrate an initial response at readily attainable nifedipine concentrations with conventional dosages, a subset of patients seem to display delayed or incomplete oral absorption; these results may facilitate the clinical use of nifedipine in patients with primary pulmonary hypertension.

Original languageEnglish (US)
Pages (from-to)996-999
Number of pages4
JournalAmerican Journal of Cardiology
Volume77
Issue number11
DOIs
StatePublished - May 1 1996

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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