Serum prolactin, psychopathology, and ventricular size in chronic schizophrenia

Daniel J. Luchins; Alan G. Robertson; Herbert Y. Meltzer

doi:10.1016/0165-1781(84)90014-3

Serum prolactin, psychopathology, and ventricular size in chronic schizophrenia

Daniel J. Luchins, Alan G. Robertson, Herbert Y. Meltzer

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Previous reports have suggested an inverse relationship between serum prolactin concentrations and psychopathology in schizophrenic patients. One such study noted this relationship to be particularly robust in schizophrenic patients with normal as compared to enlarged ventricles, as determined by computed tomography (Kleinman et al., 1982). Because of the potential implications of these findings for the dopamine hypothesis of schizophrenia, we reexamined this issue in 23 schizophrenic patients diagnosed according to Research Diagnostic Criteria. We could find no significant correlation between serum prolactin concentration and psychopathology assessed by either Brief Psychiatric Rating Scale or the Schedule for Affective Disorders and Schizophrenia, Change Form. The lack of a significant relationship was noted in patients with normal or enlarged ventricles. Possible reasons for the discrepancies between our findings and previous reports are discussed.

Original language	English (US)
Pages (from-to)	149-153
Number of pages	5
Journal	Psychiatry Research
Volume	12
Issue number	2
DOIs	https://doi.org/10.1016/0165-1781(84)90014-3
State	Published - Jun 1984

Funding

Acknowledgment. The researchr eported was supported, in part, by USPHS MH-29206and MH-30938, State of Illinois Department of Mental Health, and Brain Research Foundation, an affiliate of the University of Chicago. HYM is recipient of USPHS-RCSA MH-47808.

Keywords

Schizophrenia
computed tomography
dopamine hypothesis
lateral ventricles
psychopathology
serum prolactin

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0165-1781(84)90014-3

Cite this

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title = "Serum prolactin, psychopathology, and ventricular size in chronic schizophrenia",

abstract = "Previous reports have suggested an inverse relationship between serum prolactin concentrations and psychopathology in schizophrenic patients. One such study noted this relationship to be particularly robust in schizophrenic patients with normal as compared to enlarged ventricles, as determined by computed tomography (Kleinman et al., 1982). Because of the potential implications of these findings for the dopamine hypothesis of schizophrenia, we reexamined this issue in 23 schizophrenic patients diagnosed according to Research Diagnostic Criteria. We could find no significant correlation between serum prolactin concentration and psychopathology assessed by either Brief Psychiatric Rating Scale or the Schedule for Affective Disorders and Schizophrenia, Change Form. The lack of a significant relationship was noted in patients with normal or enlarged ventricles. Possible reasons for the discrepancies between our findings and previous reports are discussed.",

keywords = "Schizophrenia, computed tomography, dopamine hypothesis, lateral ventricles, psychopathology, serum prolactin",

author = "Luchins, {Daniel J.} and Robertson, {Alan G.} and Meltzer, {Herbert Y.}",

note = "Funding Information: Acknowledgment. The researchr eported was supported, in part, by USPHS MH-29206and MH-30938, State of Illinois Department of Mental Health, and Brain Research Foundation, an affiliate of the University of Chicago. HYM is recipient of USPHS-RCSA MH-47808.",

year = "1984",

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AU - Luchins, Daniel J.

AU - Robertson, Alan G.

AU - Meltzer, Herbert Y.

N1 - Funding Information: Acknowledgment. The researchr eported was supported, in part, by USPHS MH-29206and MH-30938, State of Illinois Department of Mental Health, and Brain Research Foundation, an affiliate of the University of Chicago. HYM is recipient of USPHS-RCSA MH-47808.

PY - 1984/6

Y1 - 1984/6

N2 - Previous reports have suggested an inverse relationship between serum prolactin concentrations and psychopathology in schizophrenic patients. One such study noted this relationship to be particularly robust in schizophrenic patients with normal as compared to enlarged ventricles, as determined by computed tomography (Kleinman et al., 1982). Because of the potential implications of these findings for the dopamine hypothesis of schizophrenia, we reexamined this issue in 23 schizophrenic patients diagnosed according to Research Diagnostic Criteria. We could find no significant correlation between serum prolactin concentration and psychopathology assessed by either Brief Psychiatric Rating Scale or the Schedule for Affective Disorders and Schizophrenia, Change Form. The lack of a significant relationship was noted in patients with normal or enlarged ventricles. Possible reasons for the discrepancies between our findings and previous reports are discussed.

AB - Previous reports have suggested an inverse relationship between serum prolactin concentrations and psychopathology in schizophrenic patients. One such study noted this relationship to be particularly robust in schizophrenic patients with normal as compared to enlarged ventricles, as determined by computed tomography (Kleinman et al., 1982). Because of the potential implications of these findings for the dopamine hypothesis of schizophrenia, we reexamined this issue in 23 schizophrenic patients diagnosed according to Research Diagnostic Criteria. We could find no significant correlation between serum prolactin concentration and psychopathology assessed by either Brief Psychiatric Rating Scale or the Schedule for Affective Disorders and Schizophrenia, Change Form. The lack of a significant relationship was noted in patients with normal or enlarged ventricles. Possible reasons for the discrepancies between our findings and previous reports are discussed.

KW - Schizophrenia

KW - computed tomography

KW - dopamine hypothesis

KW - lateral ventricles

KW - psychopathology

KW - serum prolactin

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Serum prolactin, psychopathology, and ventricular size in chronic schizophrenia

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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