TY - JOUR
T1 - Serum proteomic profiling of rheumatoid arthritis–interstitial lung disease with a comparison to idiopathic pulmonary fibrosis
AU - Wu, Xiaoping
AU - Jeong, Yunju
AU - de Frías, Sergio Poli
AU - Easthausen, Imaani
AU - Hoffman, Katherine
AU - Oromendia, Clara
AU - Taheri, Shahrad
AU - Esposito, Anthony J.
AU - Arias, Luisa Quesada
AU - Ayaub, Ehab A.
AU - Maurer, Rie
AU - Gill, Ritu R.
AU - Hatabu, Hiroto
AU - Nishino, Mizuki
AU - Frits, Michelle L.
AU - Iannaccone, Christine K.
AU - Weinblatt, Michael E.
AU - Shadick, Nancy A.
AU - Dellaripa, Paul F.
AU - Choi, Augustine M.K.
AU - Kim, Edy Y.
AU - Rosas, Ivan O.
AU - Martinez, Fernando J.
AU - Doyle, Tracy J.
N1 - Publisher Copyright:
© Author(s)
PY - 2022/7/30
Y1 - 2022/7/30
N2 - Although interstitial lung disease (ILD) causes significant morbidity and mortality in rheumatoid arthritis (RA), it is difficult to predict the development or progression of ILD, emphasising the need for improved discovery through minimally invasive diagnostic tests. Aptamer-based proteomic profiling was used to assess 1321 proteins from 159 patients with rheumatoid arthritis with interstitial lung disease (RA-ILD), RA without ILD, idiopathic pulmonary fibrosis and healthy controls. Differential expression and gene set enrichment analyses revealed molecular signatures that are strongly associated with the presence and severity of RA-ILD and provided insight into unexplored pathways of disease. These warrant further study as non-invasive diagnostic tools and future therapeutic targets.
AB - Although interstitial lung disease (ILD) causes significant morbidity and mortality in rheumatoid arthritis (RA), it is difficult to predict the development or progression of ILD, emphasising the need for improved discovery through minimally invasive diagnostic tests. Aptamer-based proteomic profiling was used to assess 1321 proteins from 159 patients with rheumatoid arthritis with interstitial lung disease (RA-ILD), RA without ILD, idiopathic pulmonary fibrosis and healthy controls. Differential expression and gene set enrichment analyses revealed molecular signatures that are strongly associated with the presence and severity of RA-ILD and provided insight into unexplored pathways of disease. These warrant further study as non-invasive diagnostic tools and future therapeutic targets.
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U2 - 10.1136/thorax-2021-217822
DO - 10.1136/thorax-2021-217822
M3 - Article
C2 - 35907639
AN - SCOPUS:85142021902
SN - 0040-6376
VL - 77
SP - 1041
EP - 1044
JO - Thorax
JF - Thorax
IS - 10
ER -