Serum S-100β response to exercise-heat strain before and after acclimation

Samuel N. Cheuvront, Troy D. Chinevere, Brett R. Ely, Robert W. Kenefick, Daniel A. Goodman, James P. McClung, Michael N. Sawka

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Exercise alone or in combination with environmental heat stress can elevate blood S-100β protein concentrations. However, the explanatory power of exercise with marked environmental heat stress on the appearance of S-100β is questionable. It is possible that the process of heat acclimation might afford additional insight. Purpose: Determine the S-100β response to moderate-intensity exercise with heat strain before and after heat acclimation. Methods: Nine healthy male volunteers completed 10 consecutive days of heat acclimation consisting of up to 100 min of treadmill walking (1.56 m·s -1, 4% grade) in the heat (45°C, 20% relative humidity). Changes in HR, rectal temperature (T re), and sweat rate (SR) were examined to determine successful acclimation. Area under the curve (AUC) for T re greater than 38.5°C was calculated to assess cumulative hyperthermia. Blood samples were taken before and after exercise on days 1 and 10 and were analyzed for serum osmolality and S-100β concentration. Results: All subjects displayed physiological adaptations to heat acclimation including a significant (P β 0.05) reduction in final HR (161 to 145 bpm) and T re (39.0 to 38.4°C), as well as a modest (∼10%) increase in SR (1.10 to 1.20 L·h -1; P = 0.09). No differences were observed in pre- to postexercise serum S-100β concentrations on day 1 or 10, and no differences were observed in S-100β values between days 1 and 10. No significant correlations were found between S-100β values and any variable of interest. Conclusions: S-100β concentrations do not necessarily increase in response to exercise-heat strain, and no effect of heat acclimation on S-100β could be observed despite other quantifiable physiological adaptations.

Original languageEnglish (US)
Pages (from-to)1477-1482
Number of pages6
JournalMedicine and science in sports and exercise
Issue number8
StatePublished - 2008


  • Blood-brain barrier
  • Heat acclimatization
  • Hyperthermia
  • Thermoregulation

ASJC Scopus subject areas

  • General Medicine


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