Serum S100B and antioxidant enzymes in bipolar patients

Ana Cristina Andreazza, Carina Cassini, Adriane Ribeiro Rosa, Marina Concli Leite, Lucia M V de Almeida, Patrícia Nardin, Angelo B N Cunha, Keila Maria Ceresér, Aida Santin, Carmem Gottfried, Mirian Salvador, Flavio Kapczinski, Carlos Alberto Gonçalves*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

227 Scopus citations


Bipolar disorder (BD) is a chronic, severe, and highly disabling psychiatric disorder; peripheral markers have been used to assess biochemical alterations associated with BD and/or possibly involved in its pathophysiology. Beyond neuronal commitment, many groups have proposed the involvement of glial activity in psychiatric disorders. Other biochemical markers, particularly associated with oxidative stress, have been studied in BD. In the present study, we evaluated glial involvement and oxidative stress in patients with BD. Glial activity was assessed by measuring serum S100B content; oxidative stress was assessed using serum thiobarbituric acid reactive substances (TBARS) and activities of antioxidant enzymes in BD patients during different episodes of disease. We found a significant increment of serum S100B during episodes of mania and depression, but not in euthymic patients. Superoxide dismutase (SOD) activity, as well the SOD/glutathione peroxidase plus catalase ratio, was also increased in manic and depressed patients. On the other hand, TBARS levels were increased in BD patients regardless of the phase of the disorder. These findings suggest a potential oxidative damage in BD patients. This peripheral oxidative imbalance indicates that systemic changes are taking place during the active phases of the illness. Such changes appear to relate to astrocyte function, as indicated by serum S100B elevation.

Original languageEnglish (US)
Pages (from-to)523-529
Number of pages7
JournalJournal of Psychiatric Research
Issue number6
StatePublished - Sep 1 2007


  • Bipolar disorder
  • Catalase
  • Glutathione peroxidase
  • Oxidative stress
  • S100B
  • Superoxide dismutase

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

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