TY - JOUR
T1 - Serum sertraline and N-desmethylsertraline levels in breast-feeding mother-infant pairs
AU - Wisner, Katherine L.
AU - Perel, James M.
AU - Blumer, Jeffrey
PY - 1998
Y1 - 1998
N2 - Objective: The authors' goal was to study the serum sertraline levels of breast-feeding mothers and their infants. Method: They obtained serum levels of sertraline and N-desmethylsertraline in nine mother-infant pairs. Results: Sertraline levels were very low (less than 2 ng/ml) in seven of the nine infants and low (3 ng/ml) in one. N-Desmethylsertraline levels were also low (6 ng/ml or less) in seven of the nine infants. One infant had a high level of N-desmethylsertraline, and one infant bad unusual serum sertraline and N- desmethylsertraline values (half of its mother's levels). All infants were thriving. Conclusions: Most breast-feeding infants whose mothers were taking sertraline had very low serum levels of both sertraline and N- desmethylsertraline, consistent with published reports. The authors discuss in detail the one infant with unusually high levels.
AB - Objective: The authors' goal was to study the serum sertraline levels of breast-feeding mothers and their infants. Method: They obtained serum levels of sertraline and N-desmethylsertraline in nine mother-infant pairs. Results: Sertraline levels were very low (less than 2 ng/ml) in seven of the nine infants and low (3 ng/ml) in one. N-Desmethylsertraline levels were also low (6 ng/ml or less) in seven of the nine infants. One infant had a high level of N-desmethylsertraline, and one infant bad unusual serum sertraline and N- desmethylsertraline values (half of its mother's levels). All infants were thriving. Conclusions: Most breast-feeding infants whose mothers were taking sertraline had very low serum levels of both sertraline and N- desmethylsertraline, consistent with published reports. The authors discuss in detail the one infant with unusually high levels.
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U2 - 10.1176/ajp.155.5.690
DO - 10.1176/ajp.155.5.690
M3 - Article
C2 - 9585724
AN - SCOPUS:0031978816
SN - 0002-953X
VL - 155
SP - 690
EP - 692
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
IS - 5
ER -