Serum small dense low-density lipoprotein concentrations are elevated in patients with significant coronary artery stenosis and are related to features of the metabolic syndrome

Shima Yazdandoust; Seyyed Mohammad Reza Parizadeh; Mohsen Moohebati; Parichehreh Yaghmaei; Amir Ali Rahsepar; Shima Tavallaie; Mohammad Soukhtanloo; Roshanak Khojasteh; Roghayeh Paydar; Afsoon Fazlinezhad; Homa Falsoleiman; Mashalla Dehghani; Majid Ghayour-Mobarhan; Gordon A. Ferns

doi:10.1007/s11745-012-3706-x

Serum small dense low-density lipoprotein concentrations are elevated in patients with significant coronary artery stenosis and are related to features of the metabolic syndrome

Shima Yazdandoust, Seyyed Mohammad Reza Parizadeh, Mohsen Moohebati, Parichehreh Yaghmaei, Amir Ali Rahsepar, Shima Tavallaie, Mohammad Soukhtanloo, Roshanak Khojasteh, Roghayeh Paydar, Afsoon Fazlinezhad, Homa Falsoleiman, Mashalla Dehghani, Majid Ghayour-Mobarhan^*, Gordon A. Ferns

^*Corresponding author for this work

Radiology

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Abstract

Serum small dense low-density lipoprotein (sd-LDL) concentrations were measured in patients with angiographically defined coronary artery disease (CAD) and compared to concentrations in healthy subjects. Five hundred and seventy patients with stable CAD were divided into CAD- and CAD+ based on angiography. Patients in whom stenosis was <50 % in diameter were classified as having a 'normal' angiogram (CAD-), otherwise the patients were allocated to the CAD+ group. The CAD+ group was further subcategorized into single-, double- and triple-vessel disease (VD). Serum sd-LDL concentrations were significantly lower in controls compared with CAD+ and CAD- patients (P<0.001). Moreover, CAD+ patients had higher concentrations of sd-LDL than CAD- patients (P < 0.01). sd-LDL levels were not significantly associated with severity of CAD defined by the number of stenosed coronary arteries (P = 0.245). All participants were also categorized into subgroups with or without metabolic syndrome. Subjects with metabolic syndrome had higher levels of sd-LDL than subjects without metabolic syndrome (P < 0.01). Multiple linear regressions showed that in CAD patients, triacylglycerol, total-cholesterol, body mass index, and waist circumferences were the most important determinants of serum sd-LDL concentrations. We found that sd-LDL levels were significantly higher in patients presenting with symptoms of CAD. Moreover, patients with significant stenosis of their coronary arteries (>50 % stenosis) had higher levels of sd-LDL compared to patients without significant lesions.

Original language	English (US)
Pages (from-to)	963-972
Number of pages	10
Journal	Lipids
Volume	47
Issue number	10
DOIs	https://doi.org/10.1007/s11745-012-3706-x
State	Published - Oct 2012

Funding

Acknowledgments The Mashhad University of Medical Science has provided the financial supports for this study. We are particularly grateful to the patients and their family members who volunteered to participate in this study. We are particularly grateful to Ms. Zahra Gharaie Sheyda for data analysis. The results presented in this work have been taken from Shima Yazdandoust’s thesis in Mashhad University of Medical Science.

Keywords

Angiography
Coronary artery disease
Metabolic syndrome
Severity
Small dense low-density lipoprotein

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Cell Biology

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Yazdandoust, S., Parizadeh, S. M. R., Moohebati, M., Yaghmaei, P., Rahsepar, A. A., Tavallaie, S., Soukhtanloo, M., Khojasteh, R., Paydar, R., Fazlinezhad, A., Falsoleiman, H., Dehghani, M., Ghayour-Mobarhan, M., & Ferns, G. A. (2012). Serum small dense low-density lipoprotein concentrations are elevated in patients with significant coronary artery stenosis and are related to features of the metabolic syndrome. Lipids, 47(10), 963-972. https://doi.org/10.1007/s11745-012-3706-x

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title = "Serum small dense low-density lipoprotein concentrations are elevated in patients with significant coronary artery stenosis and are related to features of the metabolic syndrome",

abstract = "Serum small dense low-density lipoprotein (sd-LDL) concentrations were measured in patients with angiographically defined coronary artery disease (CAD) and compared to concentrations in healthy subjects. Five hundred and seventy patients with stable CAD were divided into CAD- and CAD+ based on angiography. Patients in whom stenosis was <50 % in diameter were classified as having a 'normal' angiogram (CAD-), otherwise the patients were allocated to the CAD+ group. The CAD+ group was further subcategorized into single-, double- and triple-vessel disease (VD). Serum sd-LDL concentrations were significantly lower in controls compared with CAD+ and CAD- patients (P<0.001). Moreover, CAD+ patients had higher concentrations of sd-LDL than CAD- patients (P < 0.01). sd-LDL levels were not significantly associated with severity of CAD defined by the number of stenosed coronary arteries (P = 0.245). All participants were also categorized into subgroups with or without metabolic syndrome. Subjects with metabolic syndrome had higher levels of sd-LDL than subjects without metabolic syndrome (P < 0.01). Multiple linear regressions showed that in CAD patients, triacylglycerol, total-cholesterol, body mass index, and waist circumferences were the most important determinants of serum sd-LDL concentrations. We found that sd-LDL levels were significantly higher in patients presenting with symptoms of CAD. Moreover, patients with significant stenosis of their coronary arteries (>50 % stenosis) had higher levels of sd-LDL compared to patients without significant lesions.",

keywords = "Angiography, Coronary artery disease, Metabolic syndrome, Severity, Small dense low-density lipoprotein",

author = "Shima Yazdandoust and Parizadeh, {Seyyed Mohammad Reza} and Mohsen Moohebati and Parichehreh Yaghmaei and Rahsepar, {Amir Ali} and Shima Tavallaie and Mohammad Soukhtanloo and Roshanak Khojasteh and Roghayeh Paydar and Afsoon Fazlinezhad and Homa Falsoleiman and Mashalla Dehghani and Majid Ghayour-Mobarhan and Ferns, {Gordon A.}",

year = "2012",

month = oct,

doi = "10.1007/s11745-012-3706-x",

language = "English (US)",

volume = "47",

pages = "963--972",

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Yazdandoust, S, Parizadeh, SMR, Moohebati, M, Yaghmaei, P, Rahsepar, AA, Tavallaie, S, Soukhtanloo, M, Khojasteh, R, Paydar, R, Fazlinezhad, A, Falsoleiman, H, Dehghani, M, Ghayour-Mobarhan, M & Ferns, GA 2012, 'Serum small dense low-density lipoprotein concentrations are elevated in patients with significant coronary artery stenosis and are related to features of the metabolic syndrome', Lipids, vol. 47, no. 10, pp. 963-972. https://doi.org/10.1007/s11745-012-3706-x

Serum small dense low-density lipoprotein concentrations are elevated in patients with significant coronary artery stenosis and are related to features of the metabolic syndrome. / Yazdandoust, Shima; Parizadeh, Seyyed Mohammad Reza; Moohebati, Mohsen et al.
In: Lipids, Vol. 47, No. 10, 10.2012, p. 963-972.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Serum small dense low-density lipoprotein concentrations are elevated in patients with significant coronary artery stenosis and are related to features of the metabolic syndrome

AU - Yazdandoust, Shima

AU - Parizadeh, Seyyed Mohammad Reza

AU - Moohebati, Mohsen

AU - Yaghmaei, Parichehreh

AU - Rahsepar, Amir Ali

AU - Tavallaie, Shima

AU - Soukhtanloo, Mohammad

AU - Khojasteh, Roshanak

AU - Paydar, Roghayeh

AU - Fazlinezhad, Afsoon

AU - Falsoleiman, Homa

AU - Dehghani, Mashalla

AU - Ghayour-Mobarhan, Majid

AU - Ferns, Gordon A.

PY - 2012/10

Y1 - 2012/10

N2 - Serum small dense low-density lipoprotein (sd-LDL) concentrations were measured in patients with angiographically defined coronary artery disease (CAD) and compared to concentrations in healthy subjects. Five hundred and seventy patients with stable CAD were divided into CAD- and CAD+ based on angiography. Patients in whom stenosis was <50 % in diameter were classified as having a 'normal' angiogram (CAD-), otherwise the patients were allocated to the CAD+ group. The CAD+ group was further subcategorized into single-, double- and triple-vessel disease (VD). Serum sd-LDL concentrations were significantly lower in controls compared with CAD+ and CAD- patients (P<0.001). Moreover, CAD+ patients had higher concentrations of sd-LDL than CAD- patients (P < 0.01). sd-LDL levels were not significantly associated with severity of CAD defined by the number of stenosed coronary arteries (P = 0.245). All participants were also categorized into subgroups with or without metabolic syndrome. Subjects with metabolic syndrome had higher levels of sd-LDL than subjects without metabolic syndrome (P < 0.01). Multiple linear regressions showed that in CAD patients, triacylglycerol, total-cholesterol, body mass index, and waist circumferences were the most important determinants of serum sd-LDL concentrations. We found that sd-LDL levels were significantly higher in patients presenting with symptoms of CAD. Moreover, patients with significant stenosis of their coronary arteries (>50 % stenosis) had higher levels of sd-LDL compared to patients without significant lesions.

AB - Serum small dense low-density lipoprotein (sd-LDL) concentrations were measured in patients with angiographically defined coronary artery disease (CAD) and compared to concentrations in healthy subjects. Five hundred and seventy patients with stable CAD were divided into CAD- and CAD+ based on angiography. Patients in whom stenosis was <50 % in diameter were classified as having a 'normal' angiogram (CAD-), otherwise the patients were allocated to the CAD+ group. The CAD+ group was further subcategorized into single-, double- and triple-vessel disease (VD). Serum sd-LDL concentrations were significantly lower in controls compared with CAD+ and CAD- patients (P<0.001). Moreover, CAD+ patients had higher concentrations of sd-LDL than CAD- patients (P < 0.01). sd-LDL levels were not significantly associated with severity of CAD defined by the number of stenosed coronary arteries (P = 0.245). All participants were also categorized into subgroups with or without metabolic syndrome. Subjects with metabolic syndrome had higher levels of sd-LDL than subjects without metabolic syndrome (P < 0.01). Multiple linear regressions showed that in CAD patients, triacylglycerol, total-cholesterol, body mass index, and waist circumferences were the most important determinants of serum sd-LDL concentrations. We found that sd-LDL levels were significantly higher in patients presenting with symptoms of CAD. Moreover, patients with significant stenosis of their coronary arteries (>50 % stenosis) had higher levels of sd-LDL compared to patients without significant lesions.

KW - Angiography

KW - Coronary artery disease

KW - Metabolic syndrome

KW - Severity

KW - Small dense low-density lipoprotein

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ER -

Serum small dense low-density lipoprotein concentrations are elevated in patients with significant coronary artery stenosis and are related to features of the metabolic syndrome

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