SET for life: Biochemical activities and biological functions of SET domain-containing proteins

Hans Martin Herz, Alexander Garruss, Ali Shilatifard*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

151 Scopus citations

Abstract

SET domain-containing proteins belong to a group of enzymes named after a common domain that utilizes the cofactor S-adenosyl-. l-methionine (SAM) to achieve methylation of its substrates. Many SET domain-containing proteins have been shown to display catalytic activity towards particular lysine residues on histones, but emerging evidence also indicates that various non-histone proteins are specifically targeted by this clade of enzymes. Here, we summarize the most recent findings on the biological functions of the major families of SET domain-containing proteins catalyzing the methylation of histones 3 on lysines 4, 9, 27, and 36 (H3K4, H3K9, H3K27, and H3K36) and histone 4 on lysine 20 (H4K20), as well as enzymes that have been reported to modify non-histone substrates.

Original languageEnglish (US)
Pages (from-to)621-639
Number of pages19
JournalTrends in Biochemical Sciences
Volume38
Issue number12
DOIs
StatePublished - Dec 2013

Keywords

  • Histone lysine methylation
  • Non-histone substrates
  • SET domain-containing proteins

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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