TY - JOUR
T1 - SET-ting the stage for life and death
AU - Chakravarti, Debabrata
AU - Hong, Rui
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2003/3/7
Y1 - 2003/3/7
N2 - Cytotoxic T lymphocytes release granzymes (Gzm) A and B to induce apoptosis or programmed cell death of virally infected or tumor cells. In this issue of Cell, Fan et al. identify the tumor metastasis suppressor NM23-H1 as a GzmA-activated, apoptosis-inducing DNase and the oncoprotein SET as its inhibitor. Work from the Lieberman and Wang groups indicates a surprising role for a group of acidic nucleo-cytoplasmic proteins in regulating apoptosis.
AB - Cytotoxic T lymphocytes release granzymes (Gzm) A and B to induce apoptosis or programmed cell death of virally infected or tumor cells. In this issue of Cell, Fan et al. identify the tumor metastasis suppressor NM23-H1 as a GzmA-activated, apoptosis-inducing DNase and the oncoprotein SET as its inhibitor. Work from the Lieberman and Wang groups indicates a surprising role for a group of acidic nucleo-cytoplasmic proteins in regulating apoptosis.
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U2 - 10.1016/S0092-8674(03)00151-X
DO - 10.1016/S0092-8674(03)00151-X
M3 - Short survey
C2 - 12628178
AN - SCOPUS:0037423949
VL - 112
SP - 589
EP - 591
JO - Cell
JF - Cell
SN - 0092-8674
IS - 5
ER -