SET-ting the stage for life and death

Debabrata Chakravarti; Rui Hong

doi:10.1016/S0092-8674(03)00151-X

SET-ting the stage for life and death

Debabrata Chakravarti^*, Rui Hong

^*Corresponding author for this work

Obstetrics and Gynecology

Research output: Contribution to journal › Review article › peer-review

36 Scopus citations

Abstract

Cytotoxic T lymphocytes release granzymes (Gzm) A and B to induce apoptosis or programmed cell death of virally infected or tumor cells. In this issue of Cell, Fan et al. identify the tumor metastasis suppressor NM23-H1 as a GzmA-activated, apoptosis-inducing DNase and the oncoprotein SET as its inhibitor. Work from the Lieberman and Wang groups indicates a surprising role for a group of acidic nucleo-cytoplasmic proteins in regulating apoptosis.

Original language	English (US)
Pages (from-to)	589-591
Number of pages	3
Journal	Cell
Volume	112
Issue number	5
DOIs	https://doi.org/10.1016/S0092-8674(03)00151-X
State	Published - Mar 7 2003

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "SET-ting the stage for life and death",

abstract = "Cytotoxic T lymphocytes release granzymes (Gzm) A and B to induce apoptosis or programmed cell death of virally infected or tumor cells. In this issue of Cell, Fan et al. identify the tumor metastasis suppressor NM23-H1 as a GzmA-activated, apoptosis-inducing DNase and the oncoprotein SET as its inhibitor. Work from the Lieberman and Wang groups indicates a surprising role for a group of acidic nucleo-cytoplasmic proteins in regulating apoptosis.",

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AU - Hong, Rui

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AB - Cytotoxic T lymphocytes release granzymes (Gzm) A and B to induce apoptosis or programmed cell death of virally infected or tumor cells. In this issue of Cell, Fan et al. identify the tumor metastasis suppressor NM23-H1 as a GzmA-activated, apoptosis-inducing DNase and the oncoprotein SET as its inhibitor. Work from the Lieberman and Wang groups indicates a surprising role for a group of acidic nucleo-cytoplasmic proteins in regulating apoptosis.

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SET-ting the stage for life and death

Abstract

ASJC Scopus subject areas

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