SET-ting the stage for life and death

Debabrata Chakravarti*, Rui Hong

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

34 Scopus citations

Abstract

Cytotoxic T lymphocytes release granzymes (Gzm) A and B to induce apoptosis or programmed cell death of virally infected or tumor cells. In this issue of Cell, Fan et al. identify the tumor metastasis suppressor NM23-H1 as a GzmA-activated, apoptosis-inducing DNase and the oncoprotein SET as its inhibitor. Work from the Lieberman and Wang groups indicates a surprising role for a group of acidic nucleo-cytoplasmic proteins in regulating apoptosis.

Original languageEnglish (US)
Pages (from-to)589-591
Number of pages3
JournalCell
Volume112
Issue number5
DOIs
StatePublished - Mar 7 2003

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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