Abstract
Cytotoxic T lymphocytes release granzymes (Gzm) A and B to induce apoptosis or programmed cell death of virally infected or tumor cells. In this issue of Cell, Fan et al. identify the tumor metastasis suppressor NM23-H1 as a GzmA-activated, apoptosis-inducing DNase and the oncoprotein SET as its inhibitor. Work from the Lieberman and Wang groups indicates a surprising role for a group of acidic nucleo-cytoplasmic proteins in regulating apoptosis.
Original language | English (US) |
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Pages (from-to) | 589-591 |
Number of pages | 3 |
Journal | Cell |
Volume | 112 |
Issue number | 5 |
DOIs | |
State | Published - Mar 7 2003 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)