SET-ting the stage for life and death

Debabrata Chakravarti*, Rui Hong

*Corresponding author for this work

Research output: Contribution to journal › Short survey

34 Citations (Scopus)

Abstract

Cytotoxic T lymphocytes release granzymes (Gzm) A and B to induce apoptosis or programmed cell death of virally infected or tumor cells. In this issue of Cell, Fan et al. identify the tumor metastasis suppressor NM23-H1 as a GzmA-activated, apoptosis-inducing DNase and the oncoprotein SET as its inhibitor. Work from the Lieberman and Wang groups indicates a surprising role for a group of acidic nucleo-cytoplasmic proteins in regulating apoptosis.

Original languageEnglish (US)
Pages (from-to)589-591
Number of pages3
JournalCell
Volume112
Issue number5
DOIs
StatePublished - Mar 7 2003

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Tolnaftate
Granzymes
Apoptosis
Tumors
T-cells
Deoxyribonucleases
Oncogene Proteins
Cytotoxic T-Lymphocytes
Cell death
Neoplasms
Cell Death
Cells
Neoplasm Metastasis
Proteins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Chakravarti, Debabrata ; Hong, Rui. / SET-ting the stage for life and death. In: Cell. 2003 ; Vol. 112, No. 5. pp. 589-591.
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Chakravarti, D & Hong, R 2003, 'SET-ting the stage for life and death', Cell, vol. 112, no. 5, pp. 589-591. https://doi.org/10.1016/S0092-8674(03)00151-X

SET-ting the stage for life and death. / Chakravarti, Debabrata; Hong, Rui.

In: Cell, Vol. 112, No. 5, 07.03.2003, p. 589-591.

Research output: Contribution to journal › Short survey

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T1 - SET-ting the stage for life and death

AU - Chakravarti, Debabrata

AU - Hong, Rui

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N2 - Cytotoxic T lymphocytes release granzymes (Gzm) A and B to induce apoptosis or programmed cell death of virally infected or tumor cells. In this issue of Cell, Fan et al. identify the tumor metastasis suppressor NM23-H1 as a GzmA-activated, apoptosis-inducing DNase and the oncoprotein SET as its inhibitor. Work from the Lieberman and Wang groups indicates a surprising role for a group of acidic nucleo-cytoplasmic proteins in regulating apoptosis.

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Chakravarti D, Hong R. SET-ting the stage for life and death. Cell. 2003 Mar 7;112(5):589-591. https://doi.org/10.1016/S0092-8674(03)00151-X

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