Setting priorities for comparative effectiveness research in inflammatory bowel disease: Results of an international provider survey, expert rand panel, and patient focus groups

A. S. Cheifetz*, G. Y. Melmed, B. Spiegel, J. Talley, S. M. Devlin, L. Raffals, P. M. Irving, J. Jones, G. G. Kaplan, P. Kozuch, M. Sparrow, F. Velayos, L. Baidoo, B. Bressler, C. A. Siegel

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Background: Comparative effectiveness research (CER) is an emerging field that compares the relative effectiveness of alternative strategies to prevent, diagnose, or treat patients who are typical of day-to-day practice. We developed a priority list of CER topics for inflammatory bowel disease (IBD). Methods: Following the Institute of Medicine's approach, we developed and administered a survey to gastroenterologists asking for important CER topics in IBD. Two patient focus groups were convened to solicit additional CER studies. CER topics were presented to the expert panel using the RAND/UCLA methodology. Following initial ratings, the panel met to discuss and re-rate priorities. The top 10 CER topics were identified using a point-allocation system. Results: Responses were collated into 234 CER topics across 21 categories, of which 87 were prioritized for discussion and re-rated. Disagreement regarding priorities was observed in 5 of 87 studies. We utilized a point-allocation system to prioritize the top-10 CER topics. These related to comparing the effectiveness of: biomarkers in IBD; withdrawal of anti-tumor necrosis factor (TNF) or immunomodulators for Crohn's disease in remission; mucosal healing as an endpoint of treatment; infliximab levels versus standard infliximab dosing; anti-TNF monotherapy versus combination therapy in patients failing thiopurines; safety of long-term treatment options; anti-TNF versus thiopurines for prevention of postoperative recurrence; and treatment options for steroid-refractory UC. Conclusions: We systematically developed a list of high-priority IBD topics for CER based on a survey of gastroenterologists, expert review, and patient input. This list may guide IBD research toward the most important CER studies.

Original languageEnglish (US)
Pages (from-to)2294-2300
Number of pages7
JournalInflammatory bowel diseases
Volume18
Issue number12
DOIs
StatePublished - Dec 1 2012

Keywords

  • Crohn's disease
  • comparative effective research
  • ulcerative colitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Gastroenterology

Fingerprint Dive into the research topics of 'Setting priorities for comparative effectiveness research in inflammatory bowel disease: Results of an international provider survey, expert rand panel, and patient focus groups'. Together they form a unique fingerprint.

  • Cite this

    Cheifetz, A. S., Melmed, G. Y., Spiegel, B., Talley, J., Devlin, S. M., Raffals, L., Irving, P. M., Jones, J., Kaplan, G. G., Kozuch, P., Sparrow, M., Velayos, F., Baidoo, L., Bressler, B., & Siegel, C. A. (2012). Setting priorities for comparative effectiveness research in inflammatory bowel disease: Results of an international provider survey, expert rand panel, and patient focus groups. Inflammatory bowel diseases, 18(12), 2294-2300. https://doi.org/10.1002/ibd.22920