Seven new benzeneacetic acid derivatives and their quinone reductase activity from Eurycorymbus cavaleriei

Zhongjun Ma; Xiaoyu Zhang

doi:10.1016/j.phytol.2009.05.003

Seven new benzeneacetic acid derivatives and their quinone reductase activity from Eurycorymbus cavaleriei

Zhongjun Ma^*, Xiaoyu Zhang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

From the twigs of Eurycorymbus cavaleriei, seven new benzeneacetic acid derivatives cavaol A-G (1-7) were isolated. The structures were elucidated on the basis of the results of spectroscopic (NMR, IR, UV and MS) analysis. In the present study, the quinone reductase (QR) induction activities of compounds 1-7 were assayed. Compounds 3 and 4 showed moderate QR induction with concentrations to double the enzyme activity (CD) of 9.9 ± 0.3 and 7.9 ± 0.5 μg/mL, respectively. LC-MS-MS analysis revealed that the quinone reductase induction activity of compounds 3 and 4 was not due to alkylating the sulfhydryl groups of Keap1. There must be some other pathways for compounds 3 and 4 to induce quinone reductase.

Original language	English (US)
Pages (from-to)	152-158
Number of pages	7
Journal	Phytochemistry Letters
Volume	2
Issue number	4
DOIs	https://doi.org/10.1016/j.phytol.2009.05.003
State	Published - Nov 19 2009
Externally published	Yes

Keywords

Benzeneacetic acid derivatives
GSH conjugates
Quinone reductase induction activity

ASJC Scopus subject areas

Biotechnology
Biochemistry
Agronomy and Crop Science
Plant Science

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10.1016/j.phytol.2009.05.003

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title = "Seven new benzeneacetic acid derivatives and their quinone reductase activity from Eurycorymbus cavaleriei",

abstract = "From the twigs of Eurycorymbus cavaleriei, seven new benzeneacetic acid derivatives cavaol A-G (1-7) were isolated. The structures were elucidated on the basis of the results of spectroscopic (NMR, IR, UV and MS) analysis. In the present study, the quinone reductase (QR) induction activities of compounds 1-7 were assayed. Compounds 3 and 4 showed moderate QR induction with concentrations to double the enzyme activity (CD) of 9.9 ± 0.3 and 7.9 ± 0.5 μg/mL, respectively. LC-MS-MS analysis revealed that the quinone reductase induction activity of compounds 3 and 4 was not due to alkylating the sulfhydryl groups of Keap1. There must be some other pathways for compounds 3 and 4 to induce quinone reductase.",

keywords = "Benzeneacetic acid derivatives, GSH conjugates, Quinone reductase induction activity",

author = "Zhongjun Ma and Xiaoyu Zhang",

year = "2009",

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doi = "10.1016/j.phytol.2009.05.003",

language = "English (US)",

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journal = "Phytochemistry Letters",

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T1 - Seven new benzeneacetic acid derivatives and their quinone reductase activity from Eurycorymbus cavaleriei

AU - Ma, Zhongjun

AU - Zhang, Xiaoyu

PY - 2009/11/19

Y1 - 2009/11/19

N2 - From the twigs of Eurycorymbus cavaleriei, seven new benzeneacetic acid derivatives cavaol A-G (1-7) were isolated. The structures were elucidated on the basis of the results of spectroscopic (NMR, IR, UV and MS) analysis. In the present study, the quinone reductase (QR) induction activities of compounds 1-7 were assayed. Compounds 3 and 4 showed moderate QR induction with concentrations to double the enzyme activity (CD) of 9.9 ± 0.3 and 7.9 ± 0.5 μg/mL, respectively. LC-MS-MS analysis revealed that the quinone reductase induction activity of compounds 3 and 4 was not due to alkylating the sulfhydryl groups of Keap1. There must be some other pathways for compounds 3 and 4 to induce quinone reductase.

AB - From the twigs of Eurycorymbus cavaleriei, seven new benzeneacetic acid derivatives cavaol A-G (1-7) were isolated. The structures were elucidated on the basis of the results of spectroscopic (NMR, IR, UV and MS) analysis. In the present study, the quinone reductase (QR) induction activities of compounds 1-7 were assayed. Compounds 3 and 4 showed moderate QR induction with concentrations to double the enzyme activity (CD) of 9.9 ± 0.3 and 7.9 ± 0.5 μg/mL, respectively. LC-MS-MS analysis revealed that the quinone reductase induction activity of compounds 3 and 4 was not due to alkylating the sulfhydryl groups of Keap1. There must be some other pathways for compounds 3 and 4 to induce quinone reductase.

KW - Benzeneacetic acid derivatives

KW - GSH conjugates

KW - Quinone reductase induction activity

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JO - Phytochemistry Letters

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Seven new benzeneacetic acid derivatives and their quinone reductase activity from Eurycorymbus cavaleriei

Abstract

Keywords

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