Seventh Annual Society of Thoracic Surgeons Pedimacs Report

Pedimacs Investigators

doi:10.1016/j.athoracsur.2023.11.035

Seventh Annual Society of Thoracic Surgeons Pedimacs Report

Pedimacs Investigators

Pediatrics

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Background: The Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs), supported by The Society of Thoracic Surgeons, provides detailed information on pediatric patients supported with ventricular assist devices (VADs). Methods: From September 19, 2012, to December 31, 2022, 1463 devices in 1219 patients aged <19 years were reported to the registry from 40 North American hospitals. Results: Cardiomyopathy remains the most common underlying etiology (59%), followed by congenital heart disease (26%) and myocarditis (8%). Implantable continuous devices were most common (39%) type, followed by paracorporeal pulsatile (28%) and paracorporeal continuous (27%) devices. At 6 months after VAD implantation, a favorable outcome (transplant, recovery, or alive on device) was achieved in 85% of patients, which was greatest among those on implantable continuous VADs (92%) and least for paracorporeal continuous VADs (68%), although the patient population supported on these devices is different. Conclusions: This Seventh Pedimacs Report demonstrates the continued importance of VADs in the treatment of children. With the complexity of cardiac physiologies and sizes of patients, multiple types of devices are used, including paracorporeal continuous, paracorporeal pulsatile, and implantable continuous devices. The preoperative risk factors and differences in patient populations may account for some of the differences in survival observed among these devices. This report, along with other collaborative work, continues to advance the care of this challenging and vulnerable population.

Original language	English (US)
Pages (from-to)	690-703
Number of pages	14
Journal	Annals of Thoracic Surgery
Volume	117
Issue number	4
DOIs	https://doi.org/10.1016/j.athoracsur.2023.11.035
State	Published - Apr 2024

Funding

This study was funded by The Society of Thoracic Surgeons. All authors report administrative support and statistical analysis were provided by The Society of Thoracic Surgeons. Joseph W. Rossano reports a relationship with Bayer Corporation that includes: consulting or advisory; with Merck & Co Inc that includes: consulting or advisory; with Cytokinetics Inc that includes: consulting or advisory; with Bristol-Myers Squibb Company that includes: consulting or advisory; with Enzvyant that includes: consulting or advisory; with AskBio that includes: consulting or advisory; with BioMarin Pharmaceutical Inc that includes: consulting or advisory; and with American Regent Inc that includes: consulting or advisory. Ryan R. Davies reports a relationship with Abbott that includes: consulting or advisory. Eric R. Griffiths reports a relationship with Berlin Heart Gmbh that includes: speaking and lecture fees. Jennifer Conway reports a relationship with Abbott that includes: funding grants. David L.S. Morales reports a relationship with Abbott that includes: consulting or advisory; with SynCardia Systems LLC that includes: consulting or advisory; with Berlin Heart Gmbh that includes: consulting or advisory; and with PECA Labs that includes: consulting or advisory. James K. Kirklin reports a relationship with Kirklin Solutions that includes: partial ownership. David M. Peng is on the Data Safety Monitoring Board for the Berlin Heart EXCOR Active Driving System Study (NCT05610787). The other authors have no conflicts of interest to disclose. Originally supported by the National Institutes of Health, the Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs) began in 2012. Pedimacs was designed as a registry for pediatric patients (age <19 years at implantation) supported on ventricular assist devices (VADs) and was developed with data elements specific to the care and complexity of children with heart failure. 1 Pedimacs was developed as part of the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS), and both registries are supported by but remain distinct registries within The Society of Thoracic Surgeons and its national database.

ASJC Scopus subject areas

Surgery
Pulmonary and Respiratory Medicine
Cardiology and Cardiovascular Medicine

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10.1016/j.athoracsur.2023.11.035

Cite this

@article{92baffa1ff6249258087c6a3e2d05abd,

title = "Seventh Annual Society of Thoracic Surgeons Pedimacs Report",

abstract = "Background: The Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs), supported by The Society of Thoracic Surgeons, provides detailed information on pediatric patients supported with ventricular assist devices (VADs). Methods: From September 19, 2012, to December 31, 2022, 1463 devices in 1219 patients aged <19 years were reported to the registry from 40 North American hospitals. Results: Cardiomyopathy remains the most common underlying etiology (59%), followed by congenital heart disease (26%) and myocarditis (8%). Implantable continuous devices were most common (39%) type, followed by paracorporeal pulsatile (28%) and paracorporeal continuous (27%) devices. At 6 months after VAD implantation, a favorable outcome (transplant, recovery, or alive on device) was achieved in 85% of patients, which was greatest among those on implantable continuous VADs (92%) and least for paracorporeal continuous VADs (68%), although the patient population supported on these devices is different. Conclusions: This Seventh Pedimacs Report demonstrates the continued importance of VADs in the treatment of children. With the complexity of cardiac physiologies and sizes of patients, multiple types of devices are used, including paracorporeal continuous, paracorporeal pulsatile, and implantable continuous devices. The preoperative risk factors and differences in patient populations may account for some of the differences in survival observed among these devices. This report, along with other collaborative work, continues to advance the care of this challenging and vulnerable population.",

author = "{Pedimacs Investigators} and Peng, {David M.} and Davies, {Ryan R.} and Simpson, {Kathleen E.} and Shugh, {Svetlana B.} and Morales, {David L.S.} and Jacobs, {Jeffrey P.} and Arene Butto and Anna Joong and Jennifer Conway and Kerry Schindler and Griffiths, {Eric R.} and Devin Koehl and Cantor, {Ryan S.} and Kirklin, {James K.} and Rossano, {Joseph W.} and Iki Adachi",

note = "Publisher Copyright: {\textcopyright} 2024 The Society of Thoracic Surgeons",

year = "2024",

month = apr,

doi = "10.1016/j.athoracsur.2023.11.035",

language = "English (US)",

volume = "117",

pages = "690--703",

journal = "Annals of Thoracic Surgery",

issn = "0003-4975",

publisher = "Elsevier Inc.",

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TY - JOUR

T1 - Seventh Annual Society of Thoracic Surgeons Pedimacs Report

AU - Pedimacs Investigators

AU - Peng, David M.

AU - Davies, Ryan R.

AU - Simpson, Kathleen E.

AU - Shugh, Svetlana B.

AU - Morales, David L.S.

AU - Jacobs, Jeffrey P.

AU - Butto, Arene

AU - Joong, Anna

AU - Conway, Jennifer

AU - Schindler, Kerry

AU - Griffiths, Eric R.

AU - Koehl, Devin

AU - Cantor, Ryan S.

AU - Kirklin, James K.

AU - Rossano, Joseph W.

AU - Adachi, Iki

PY - 2024/4

Y1 - 2024/4

N2 - Background: The Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs), supported by The Society of Thoracic Surgeons, provides detailed information on pediatric patients supported with ventricular assist devices (VADs). Methods: From September 19, 2012, to December 31, 2022, 1463 devices in 1219 patients aged <19 years were reported to the registry from 40 North American hospitals. Results: Cardiomyopathy remains the most common underlying etiology (59%), followed by congenital heart disease (26%) and myocarditis (8%). Implantable continuous devices were most common (39%) type, followed by paracorporeal pulsatile (28%) and paracorporeal continuous (27%) devices. At 6 months after VAD implantation, a favorable outcome (transplant, recovery, or alive on device) was achieved in 85% of patients, which was greatest among those on implantable continuous VADs (92%) and least for paracorporeal continuous VADs (68%), although the patient population supported on these devices is different. Conclusions: This Seventh Pedimacs Report demonstrates the continued importance of VADs in the treatment of children. With the complexity of cardiac physiologies and sizes of patients, multiple types of devices are used, including paracorporeal continuous, paracorporeal pulsatile, and implantable continuous devices. The preoperative risk factors and differences in patient populations may account for some of the differences in survival observed among these devices. This report, along with other collaborative work, continues to advance the care of this challenging and vulnerable population.

AB - Background: The Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs), supported by The Society of Thoracic Surgeons, provides detailed information on pediatric patients supported with ventricular assist devices (VADs). Methods: From September 19, 2012, to December 31, 2022, 1463 devices in 1219 patients aged <19 years were reported to the registry from 40 North American hospitals. Results: Cardiomyopathy remains the most common underlying etiology (59%), followed by congenital heart disease (26%) and myocarditis (8%). Implantable continuous devices were most common (39%) type, followed by paracorporeal pulsatile (28%) and paracorporeal continuous (27%) devices. At 6 months after VAD implantation, a favorable outcome (transplant, recovery, or alive on device) was achieved in 85% of patients, which was greatest among those on implantable continuous VADs (92%) and least for paracorporeal continuous VADs (68%), although the patient population supported on these devices is different. Conclusions: This Seventh Pedimacs Report demonstrates the continued importance of VADs in the treatment of children. With the complexity of cardiac physiologies and sizes of patients, multiple types of devices are used, including paracorporeal continuous, paracorporeal pulsatile, and implantable continuous devices. The preoperative risk factors and differences in patient populations may account for some of the differences in survival observed among these devices. This report, along with other collaborative work, continues to advance the care of this challenging and vulnerable population.

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AN - SCOPUS:85183556137

SN - 0003-4975

VL - 117

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EP - 703

JO - Annals of Thoracic Surgery

JF - Annals of Thoracic Surgery

IS - 4

ER -

Seventh Annual Society of Thoracic Surgeons Pedimacs Report

Abstract

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