Severe acidosis and subsequent neurologic status

Susan C. Fee*, Kathleen M Malee, Ruth Deddish, John P. Minogue, Michael L Socol

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

95 Scopus citations

Abstract

To examine the relationship between severe acidosis at birth and evidence of subsequent neurologic dysfunction, a 4-year review was performed encompassing 15,528 neonates. One hundred forty-two (0.91%) of these neonates had an umbilical cord arterial pH ≤7.05 with a base deficit ≥10 mEq/L. Neurologic assessments found 101 of 110 term neonates (91.8%) and 17 of 32 preterm neonates (53.1%) with severe acidosis to be free of neurologic deficits at the time of hospital discharge. Follow-up developmental evaluation data were available for 7 of 9 term neonates and 8 of 15 preterm neonates with abnormal examinations. Although 5 term and 6 preterm infants demonstrated mild developmental delays or mild tone abnormalities in the first year of life, none exhibited a major motor or cognitive abnormality at 12 to 24 months of age. Consequently, acidosis in umbilical cord blood, even when severe, is a poor predictor of subsequent neurologic dysfunction.

Original languageEnglish (US)
Pages (from-to)802-806
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume162
Issue number3
DOIs
StatePublished - Jan 1 1990

Keywords

  • Acidosis
  • neurologic dysfunction

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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