Severe acute respiratory syndrome coronavirus 2 infection and critically ill children

Rahul Damania, Whitney Moore, Heather C. Viamonte, Pradip Kamat, Rajit K. Basu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Purpose of review: Amidst an ongoing pandemic, the delineation of the pediatric consequence of infection from the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) virus is emerging. This review summarizes available pediatric data and covers the aspects of epidemiology, critical illness with acute infection [coronavirus disease 2019 (COVID-19)], the discovered multi-inflammatory syndrome in children (MIS-C), and management options. Recent findings: The available data from the source of the initial viral transmission and then through Europe, Africa, and the Western Hemisphere identifies important aspects of the SARS-CoV2 pandemic: 1) Pediatric infection occurs commonly, is likely underestimated, and transmission patterns remain incompletely described, 2) Pediatric patients suffer multiple end-organ injuries but COVID-19 is not the same prevalence in terms of severity as in adults, 3) MIS-C is a novel and life-threatening manifestation of exposure to the virus, 4) Management using a combination of supportive care, standard practice intensive care management, and anti-inflammatory agents is associated with recovery, 5) Long-term sequelae of viral exposure is unknown at this time. Summary: Emerging evidence suggests pediatric patients are at risk for severe and life-threatening effects of exposure to SARS-CoV2. As the pandemic continues, further research is warranted - particularly as a vaccine is not yet available for use in children.

Original languageEnglish (US)
Pages (from-to)286-291
Number of pages6
JournalCurrent opinion in pediatrics
Issue number3
StatePublished - Apr 2 2021


  • Multi-inflammatory syndrome in children
  • Pandemic
  • Pediatric intensive care
  • Severe acute respiratory syndrome coronavirus 2

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Severe acute respiratory syndrome coronavirus 2 infection and critically ill children'. Together they form a unique fingerprint.

Cite this