Abstract
• Twenty-one severe reactions to hemodialysis occurred in approximately 260,000 dialysis treatments at three centers within a 10½-year period. Reactions typically appeared within minutes of initiating dialysis, and were characterized by cardiopulmonary, mucocutaneous, and/or gastrointestinal tract symptoms highly suggestive of anaphylaxis. Four respiratory arrests and one death resulted. Analysis of dialyzer use patterns and of each patient’s dialyzer exposure history strongly implicated hollow-fiber dialyzers made of cuprammonium cellulose (CC) as a cause of these reactions. No obvious factors could be found to identify predisposed patients. Less than optimal rinsing of the CC hollow-fiber dialyzers prior to use may have been responsible for some, but not all, of these reactions.
Original language | English (US) |
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Pages (from-to) | 489-494 |
Number of pages | 6 |
Journal | Archives of Internal Medicine |
Volume | 145 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1985 |
Externally published | Yes |
ASJC Scopus subject areas
- Internal Medicine