Severe community-acquired pneumonia and PIRO: A new paradigm of management

Jordi Rello*, Thiago Lisboa, Richard Wunderink

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Appropriate antibiotic management and aggressive supportive therapy is not enough to improve survival in severe community-acquired pneumonia (sCAP), a systemic syndrome involving infectious organisms, inflammation, and coagulation systems. A sepsis severity staging system focused on predisposition, insult, deleterious response, and organ failure (PIRO) provides a useful basis for risk stratification and therapy. A new paradigm of management is suggested based on early identification of patients at risk, aggressive management, modulation of host response, and need for adjunctive therapy. The CAP-PIRO score is a new, simple tool stratifying patients in four categories and may be useful for early identification of patients who may benefit from adjunctive therapy.

Original languageEnglish (US)
Pages (from-to)343-348
Number of pages6
JournalCurrent Infectious Disease Reports
Issue number5
StatePublished - Aug 31 2009

ASJC Scopus subject areas

  • Infectious Diseases

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