Severe neonatal enteroviral hepatitis treated with pleconaril

Eyglo Aradottir*, Estella M Alonso, Stanford T Shulman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Neonatal enteroviral hepatitis carries high morbidity and mortality. We treated three full term neonates with severe enteroviral hepatitis with pleconaril on an open label compassionate use protocol. Each mother had history of a viral-like syndrome within 1 week before delivery. The neonates presented at 4 to 5 days of age with fulminant hepatic failure with severe coagulopathy, and each yielded an echovirus. All were treated with pleconaril (VP63843) at 5 mg/kg every 8 h by nasogastric tube. Two of the three neonates with life-threatening enteroviral hepatitis recovered fully. Further experience with pleconaril for neonatal enteroviral hepatitis is warranted.

Original languageEnglish (US)
Pages (from-to)457-459
Number of pages3
JournalPediatric Infectious Disease Journal
Volume20
Issue number4
DOIs
StatePublished - Apr 24 2001

Keywords

  • Neonatal enteroviral hepatitis
  • Pleconaril

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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